Patrick Sachs

ASSOCIATE PROFESSOR
Medical Diagnostic & Translational Sciences

Contact Information

2130 HEALTH SCIENCES BLDG
NORFOLK, VA 23529

Biography

Dr. Sachs received his Ph.D. from the Medical College of Virginia in the Department of Human and Molecular Genetics, where he studied adult and pluripotent stem cell biology specifically related to the regulation of the enzyme telomerase. In his post-doctoral work, he studied the heterotypic interactions of breast cancer cells with adult stem cells in a mouse model. As a scientist for LifeNet Health, Patrick led efforts to generate induced pluripotent stem cells from normal and diseased donor cells and expanded LifeNet’s tissue engineering capabilities to include cell-centric grafts and therapies. At ODU Dr. Sachs studies the biology of stem cells, regenerative medicine, tissue engineering, cancer biology and neurobiology

Education/Credentials

Web Link(s)

ODU Stem Cell Lab

Expertise

Biotechnology

Tissue Engineering, Regenerative Medicine, Neurobiology, Stem Cell Biology, Cancer Biology
Research Interests

The Sachs lab focuses on the study of regenerative medicine/tissue engineering, the induction of pluripotency in normal somatic cells (iPSC), cancer biology and the stem cell niche.

Articles

Mollica, P., Booth-Creech, E. N., Reid, J. A., Zamponi, M., Sullivan, S. M., Palmer, X. L., Sachs, P., and Bruno, R. (2019). 3D bioprinted mammary organoids and tumoroids in human mammary derived ECM hydrogels.. Acta biomaterialia, 95, pp. 201-213.

Reid, J. A., Palmer, X. L., Mollica, P., Northam, N., Sachs, P., and Bruno, R. (2019). A 3D bioprinter platform for mechanistic analysis of tumoroids and chimeric mammary organoids.. Scientific reports, 9 (1), pp. 7466.

Reid, J. A., Mollica, P., Bruno, R., and Sachs, P. (2018). Consistent and reproducible cultures of large-scale 3D mammary epithelial structures using an accessible bioprinting platform.. Breast cancer research : BCR, 20 (1), pp. 122.

Mollica, P., Zamponi, M., Reid, J. A., Sharma, D. K., White, A. E., Ogle, R., Bruno, R., and Sachs, P. (2018). Epigenetic alterations mediate iPSC-induced normalization of DNA repair gene expression and TNR stability in Huntington's disease cells.. Journal of cell science, 131 (13),

Mollica, P. A., Zamponi, M., Reid, J. A., Sharma, D. K., White, A. E., Ogle, R., Bruno, R., and Sachs, P. (2018). Epigenetic alterations mediate iPSC normalization of DNA-repair expression and TNR stability in Huntington's disease.. Journal of cell science

Wu, V., Auchman, M., Mollica, P. A., Sachs, P., and Bruno, R. (2018). ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis.. Pathology

Petrella, R. A., Mollica, P. A., Zamponi, M., Reid, J. A., Xiao, S., Bruno, R., and Sachs, P. (2018). 3D bioprinter applied picosecond pulsed electric fields for targeted manipulation of proliferation and lineage specific gene expression in neural stem cells.. Journal of neural engineering

Sachs, P., Mollica, P. A., and Bruno, R. (2017). Tissue specific microenvironments: a key tool for tissue engineering and regenerative medicine.. Journal of biological engineering, 11, pp. 34.

Roberts, C. L., Chen, S. S., Murchison, A. C., Ogle, R., Francis, M. P., Ogle, R. C., and Sachs, P. (2017). Preferential Lineage-Specific Differentiation of Osteoblast-Derived Induced Pluripotent Stem Cells into Osteoprogenitors.. Stem cells international, 2017, pp. 1513281.

Mollica, P. A., Reid, J. A., Ogle, R., Sachs, P., and Bruno, R. (2016). DNA Methylation Leads to DNA Repair Gene Down-Regulation and Trinucleotide Repeat Expansion in Patient-Derived Huntington Disease Cells.. The American journal of pathology, 186 (7), pp. 1967-76.

Reid, J. A., Mollica, P. A., Johnson, G. D., Ogle, R., Bruno, R., and Sachs, P. (2016). Accessible bioprinting: adaptation of a low-cost 3D-printer for precise cell placement and stem cell differentiation.. Biofabrication, 8 (2), pp. 025017.

Francis, M. P., Moghaddam-White, Y. M., Sachs, P., Beckman, M. J., Chen, S. M., Bowlin, G. L., Elmore, L. W., and Holt, S. E. (2016). Modeling early stage bone regeneration with biomimetic electrospun brinogen nano bers and adipose-derived mesenchymal stem cells. Electrospinning

Sachs, P., Francis, M. P., Zhao, M., Brumelle, J., Rao, R. R., Elmore, L. W., and Holt, S. E. (2012). Defining essential stem cell characteristics in adipose-derived stromal cells extracted from distinct anatomical sites.. Cell and tissue research, 349 (2), pp. 505-15.

Francis, M. P., Sachs, P., Madurantakam, P. A., Sell, S. A., Elmore, L. W., Bowlin, G. L., and Holt, S. E. (2012). Electrospinning adipose tissue-derived extracellular matrix for adipose stem cell culture.. Journal of biomedical materials research. Part A, 100 (7), pp. 1716-24.

Zhao, M., Sachs, P., Wang, X., Dumur, C. I., Idowu, M. O., Robila, V., Francis, M. P., Ware, J., Beckman, M., Rizki, A., Holt, S. E., and Elmore, L. W. (2012). Mesenchymal stem cells in mammary adipose tissue stimulate progression of breast cancer resembling the basal-type.. Cancer biology & therapy, 13 (9), pp. 782-92.

Sachs, P., Francis, M. P., Elmore, L. W., and Holt, S. E. (2010). Isolating adipose-derived mesenchymal stem cells from lipoaspirate blood and saline fraction.. Organogenesis, 6 (1), pp. 11-4.

Poynter, K. R., Sachs, P., Bright, A. T., Breed, M. S., Nguyen, B. N., Elmore, L. W., and Holt, S. E. (2009). Genetic inhibition of telomerase results in sensitization and recovery of breast tumor cells.. Molecular cancer therapeutics, 8 (5), pp. 1319-27.
Book Chapters

Deprynski, A. N., Sachs, P., and Holt, S. E. (2009). Regulation of Telomerase Through Transcriptional and Post-translational Mechanisms.Telomeres and telomerase in cancer (pp. 47-85)
Presentations

Reid, J., Mollica, P., Sachs, P., and Bruno, R. (June 11, 2017). 3D bioprinted human breast cancer and mammary epithelial cell chimeric organoids for the study of microenvironmental control of breast cancer Poster presented at Gordon Research Mammary Biology Conference Stowe, VT.

Reid, J., Mollica, P., Bruno, R., and Sachs, P. (June 11, 2017). 3D bioprinting of mammary structures into biomimetic human breast tissue derived hydrogels Poster presented at Gordon Research Mammary Biology Conference Stowe, VT.

Reid, J., Mollica, P., Bruno, R., and Sachs, P. (May 2, 2017). Microextrusion based bioprinting apparatus provides valuable method for exploring the 'self - organization' of mammary epithelial branching morphogenesis Poster presented at 3D Bioprinting: Physical and Chemical Processes Winstom Salem.

Reid, J., Mollica, P., Ogle, R., Sachs, P., and Bruno, R. (December 13, 2016). Directed Mammary Epithelial Structure Formation Using 3D Bioprinting Poster presented at Tissue Engineering and Regenerative Medicine International Society Meeting San Diego, CA.

Mollica, P., Reid, J., Ogle, R., Bruno, R., and Sachs, P. (December 11, 2016). Huntington’s Disease Induced-Pluripotent Stem Cell Derived Neural Stem Cells Show Minimal Trinucleotide Repeat Instability Poster presented at Tissue Engineering and Regenerative Medicine International Society Meeting San Diego, CA.

Sachs, P., and Bruno, R. (2015). Luminal and basal breast cancer tumors retain identical differentiation repertoire upon redirection in a normal mammary microenvironment Poster presented at Gordon Research Mammary Biology Conference West Dover, VT.

Treadwell, M., Bruno, R., and Sachs, P. (2014). iPSC Reprogramming and Viral Targeting Poster presented at Biotech Seminar.

Roberts, C., Ogle, R., and Sachs, P. (2014). Reprogramming Donor Cells and Differentiation to Definitive Endodermal Cells Poster presented at CNU seminar.

Roberts, C., Ogle, R., and Sachs, P. (2014). Generation of iPSCs from Human Primary Osteoblasts Poster presented at International Society for Stem Cell Research 12th Annual Meeting Boston, MA.

Reid, J., Mollica, P., Ogle, R., Bruno, R., and Sachs, P. (2014). Cost effective bioprinting apparatus for 3D study of developmental biomimetic microenvironments Poster presented at NeuroConnections.

Roberts, C., Ogle, R., and Sachs, P. (2014). Reprogramming, and Differentiation of Human Donor Cells Oral Presentation presented at Regenerative Medicine Seminar.

Roberts, C., Ogle, R., and Sachs, P. (2013). Novel Methods of Inducing Differentiation of Definitive Endodermal Cells from Human iPSC: Growth and Phenotypic Maintenance of Definitive Endoderm Oral Presentation presented at Graduate Student Symposium.

Roberts, C., Ogle, R., and Sachs, P. (2013). Derivation, differentiation, and growth of definitive endodermal cells from reprogrammed donor fibroblasts Poster presented at International Society for Stem Cell Research 11th Annual Meeting Boston, MA.

Bristol, M., Elmore, L., and Sachs, P. (2012). Breast adipose mesenchymal stem cells and mammary fibrosis Poster presented at AACR 103rd Annual Meeting Chicago, IL.

Sachs, P., and Elmore, L. (2010). Resident Mesenchymal Stem Cells and Breast Cancer Vascularity: Are they Linked? Poster presented at Massey Cancer Center Symposium.

Sachs, P., Francis, M., and Holt, S. (2009). Recapitulating Osteogenisis with Electrospun Fibrinogen Nanofibers and Adipose Stem Cells Poster presented at 31st Annual Conference American Society for Bone and Mineral Research Baltimore, MD.

Sachs, P., and Holt, S. (2009). Comprehensive Characterization and Comparison of Adipose Stem Cells, Bone Marrow Mesenchymal Stem Cells and Fibroblasts Poster presented at The 37th Annual Forbes Day Colloquim.

Sachs, P., and Francis, M. (2008). Autologous Adipose Stem Cells and Electrospun Biomimetic Scaffolds for Individualized Regenerative Medicine Poster presented at Daniel T. Watts Graduate Research Poster Symposium.

Sachs, P., Francis, M., and Holt, S. (2008). Differentiation and viability of Adipose stem cells isolated from sonicated lipoaspirate Poster presented at Daniel T. Watts Graduate Research Poster Symposium.

Sachs, P., Francis, M., and Bowlin, G. (2008). Breast Reconstruction using Patient-Derived Adipose Stem Cells Autologous Electrospun Fat Poster presented at TERMIS Annual Meeting Hilton Head, NC.

Ma, P., Sachs, P., and Elmore, L. (2007). Signaling Pathways in Cancer and Development Poster presented at Keystone Symposium Steamboat Springs, CO.

Sachs, P., and Holt, S. (2007). Advancement of the differentiation and viability of mesenchymal stem cells: An embryonic stem cell alternative? Poster presented at The Stem Cell Summit Boston, MA.

Sachs, P., and Francis, M. (2007). Electrospun Autologous Fat ECM and Fibrinogen with Adipose Stem Cells: Individualized Regenerative Medicine Approaches Poster presented at The Stem Cell Summit Boston, MA.

Sachs, P., and Holt, S. (2002). Telomerase expression in a prostate model system Oral Presentation presented at 80th Annual meeting of the Virginia Academy of Science.

2015: ODU teaching Excellence Award, Old Dominion University

Contracts, Grants and Sponsored Research

Sachs, P.; Bruno, R. ""A three dimensional bioprinting approach to mapping critical determinants of stem cell asymmetric divisions"" $451,210. Federal. January, 2019 - December, 2022

Sachs, P.; Bruno, R.; Mollica, P.; Xiao, S. " "Investigating the effects of sub-nanosecond pulsed electric fields as a potential protein disaggregation agent in Huntington’s disease and Alzheimer’s disease neurons" " $45,000. State. July, 2018 - September, 2019

Sachs, P.; Bruno, R. "Three-dimensional bioprinting for high-throughput in-vitro of modeling of asymmetric stem cell divisions" $100,000. Other. June 30, 2017 - March 30, 2019

Sachs, P.; Bruno, R. "Chimeric mammary tissues as models for tumor suppression and promotion" $306,000. State. July, 2015 - August, 2017

Sachs, P.; Bruno, R. "Development of a Three-Dimensional Human Breast Model for the Advancement of the in vitro Study of Breast Cancer" $50,000. Old Dominion University. December, 2013 - December, 2014

Sachs, P. "Cell specific targeted viral infections for the improvement of in vitro and in vivo viral response" $7,000. Old Dominion University. June, 2014 - August, 2014
Intellectual Property

SYSTEMS AND METHODS FOR DELIVERY OF PULSED ELECTRIC FIELDS TO CELLS AND TISSUE

Patent/Copyright: Patent

Type: Provisional

Patent Nationality: United States

Inventors:
Bruno, R.
Sachs, P.
Xiao, S.
Mollica, P.
Petrella, R.

Old Dominion University

Idea Fusion

Patrick Sachs

Patrick Sachs

Contact Information

Organizational Chart

Biography

Education/Credentials

Web Link(s)

Expertise

Research Interests

Articles

Book Chapters

Presentations

Contracts, Grants and Sponsored Research

Intellectual Property