Assistant Professor
Biological Sciences

Lisa Shollenberger

202 J Mills Godwin Bldg
Norfolk, 23529

Dr. Shollenberger is an interdisciplinary and collaborative researcher focused on improving human health and mentoring the next generation of scientists.

Ph.D. in Biochemistry & Molecular Genetics, University of Pittsburgh, (2009)

Expertise

Biology
immunology, vaccinology, parasitology, infectious diseases, microbiology, drug and gene delivery, nanotechnology

Research Interests

The long term goal of my research program is to produce more effective vaccines, specifically designed with target populations in mind, by understanding the mechanisms of vaccine efficacy in the context of confounding factors. The objectives of my funded research program are to improve vaccine efficacy for high-risk and immune-suppressed populations, such as the elderly and helminth-infected, by: (1) interrogating the host-parasite-vaccine tripartite relationship, (2) understanding the contribution of the microbiome to vaccine efficacy, and (3) modifying delivery of vaccines and the way in which vaccines interact with the immune system.

Articles

Grenfell, R. F.. (2015). Vaccine Self-Assembling Immune Matrix Is a New Delivery Platform That Enhances Immune Responses to Recombinant HBsAg in Mice. Clinical and Vaccine Immunology 22 (3) , pp. 336-343.
Da'Dara, A. (2019). Prime-boost vaccine regimen for SjTPI and SjC23 schistosome vaccines, increases efficacy in water buffalo in a field trial in China. Frontiers in immunology 10 , pp. 284.
Shollenberger, L. (2013). Successful vaccination of immune suppressed recipients using Listeria vector HIV-1 vaccines in helminth infected mice. Vaccine 31 (16) , pp. 2050-2056.
Shollenberger, L. (2013). HIV-1 vaccine-specific responses induced by Listeria vector vaccines are maintained in mice subsequently infected with a model helminth parasite, Schistosoma mansoni. Vaccine 31 (48) , pp. 5651-5658.
Liu, F. (2004). Non-immunostimulatory nonviral vectors. The FASEB Journal 18 (14) , pp. 1779-1781.
Liu, F. (2007). Novel nonviral vectors target cellular signaling pathways: Regulated gene expression and reduced toxicity. Journal of Pharmacology and Experimental Therapeutics 321 (2) , pp. 777-783.
Liu, F. (2007). Mechanism of naked DNA clearance after intravenous injection. The Journal of Gene Medicine 9 (7) , pp. 613-619.
Liu, F. (2006). Mechanism of in vivo DNA transport into cells by electroporation: electrophoresis across the plasma membrane may not be involved. The Journal of Gene Medicine 8 (3) , pp. 353-361.
Liu, F. (2007). Sine-wave current for efficient and safe in vivo gene transfer. Molecular Therapy 15 (10) , pp. 1842-1847.
Liao, C. (2003). Detection of Salmonella by indicator agar media and PCR as affected by alfalfa seed homogenates and native bacteria. Letters in Applied Microbiology 36 (3) , pp. 152-156.
Liao, C. (2003). Survivability and long-term preservation of bacteria in water and in phosphate-buffered saline. Letters in Applied Microbiology 37 (1) , pp. 45-50.
LIAO, C. H.. (2003). Lethal and Sublethal Action of Acetic Acid on Salmonella In Vitro and on Cut Surfaces of Apple Slices. Journal of Food Science 68 (9) , pp. 2793-2798.
Liao, C. (2004). Enumeration, Resuscitation, and Infectivity of the Sublethally Injured Erwinia Cells Induced by Mild Acid Treatment. Phytopathology 94 (1) , pp. 76-81.
Silva-Moraes, V. (2019). Diagnosis of Schistosoma mansoni infections: what are the choices in Brazilian low-endemic areas?. Mem\'orias do Instituto Oswaldo Cruz 114.
Williams, G. (2019). Field testing integrated interventions for schistosomiasis elimination in the People’s Republic of China: Outcomes of a multifactorial cluster-randomised controlled trial. Frontiers in immunology 10 , pp. 645.
Da'Dara, A. (2019). Prime-boost vaccine regimen for SjTPI and SjC23 schistosome vaccines, increases efficacy in water buffalo in a field trial in China. Frontiers in immunology 10 , pp. 284.
Silva-Moraes, V. (2019). Serological proteomic screening and evaluation of a recombinant egg antigen for the diagnosis of low-intensity Schistosoma mansoni infections in endemic area in Brazil. PLoS neglected tropical diseases 13 (3) , pp. e0006974.
Bui, C. T.. (2015). Schistosoma mansoni Soluble Egg Antigens Enhance T Cell Responses to a Newly Identified HIV-1 Gag H-2(b) Epitope. Clinical and Vaccine Immunology 22 (2) , pp. 193-199.
Grenfell, R. F.. (2015). Vaccine Self-Assembling Immune Matrix Is a New Delivery Platform That Enhances Immune Responses to Recombinant HBsAg in Mice. Clinical and Vaccine Immunology 22 (3) , pp. 336-343.
Bui, C. T.. (2014). Schistosoma mansoni Soluble Egg Antigens Enhance Listeria monocytogenes Vector HIV-1 Vaccine Induction of Cytotoxic T Cells. Clinical and Vaccine Immunology 21 (9) , pp. 1232-1239.
Shollenberger, L. (2013). HIV-1 vaccine-specific responses induced by Listeria vector vaccines are maintained in mice subsequently infected with a model helminth parasite, Schistosoma mansoni. Vaccine 31 (48) , pp. 5651-5658.
Shollenberger, L. (2013). Successful vaccination of immune suppressed recipients using Listeria vector HIV-1 vaccines in helminth infected mice. Vaccine 31 (16) , pp. 2050-2056.
Liu, F. (2007). Novel nonviral vectors target cellular signaling pathways: Regulated gene expression and reduced toxicity. Journal of Pharmacology and Experimental Therapeutics 321 (2) , pp. 777-783.
Liu, F. (2007). Sine-wave current for efficient and safe in vivo gene transfer. Molecular Therapy 15 (10) , pp. 1842-1847.
Liu, F. (2007). Mechanism of naked DNA clearance after intravenous injection. The Journal of Gene Medicine 9 (7) , pp. 613-619.
Liu, F. (2006). Mechanism of in vivo DNA transport into cells by electroporation: electrophoresis across the plasma membrane may not be involved. The Journal of Gene Medicine 8 (3) , pp. 353-361.
Liu, F. (2004). Non-immunostimulatory nonviral vectors. The FASEB Journal 18 (14) , pp. 1779-1781.
Liao, C. (2004). Enumeration, Resuscitation, and Infectivity of the Sublethally Injured Erwinia Cells Induced by Mild Acid Treatment. Phytopathology 94 (1) , pp. 76-81.
Liao, C. (2003). Detection of Salmonella by indicator agar media and PCR as affected by alfalfa seed homogenates and native bacteria. Letters in Applied Microbiology 36 (3) , pp. 152-156.
Liao, C. (2003). Survivability and long-term preservation of bacteria in water and in phosphate-buffered saline. Letters in Applied Microbiology 37 (1) , pp. 45-50.
LIAO, C. H.. (2003). Lethal and Sublethal Action of Acetic Acid on Salmonella In Vitro and on Cut Surfaces of Apple Slices. Journal of Food Science 68 (9) , pp. 2793-2798.

Book Chapters

Shollenberger, L. (2006). Liposome-Polycation-DNA Liposome Technology, Volume II (pp. 245-252) Informa Healthcare.

Conference Proceeding

Shollenberger, L. (2019). The “Crisis of Reproducibility” of Animal Studies: Causes and Solutions American Association of Immunologists.
Shollenberger, L. (2018). Immunogenicity and Efficacy of Malarial CelTOS and CSP Vaccine Antigens Administered with Gel-Depot Adjuvant American Journal of Tropical Medicine and Hygiene (pp. 135--135).
Silva-Moraes, V. (2017). An egg protein from Schistosoma mansoni is promising for development of high-specificity diagnostics in the era of intensified control (pp. 384-384) American Journal of Tropical Medicine and Hygeine.
Harn, D. (2017). LNFPIII-Dex conjugates function in vivo to normalize metabolic function in High-Fat Diet Obese mice (pp. 1190-1191) Glycobiology.
Grenfell e Queiroz, Rafaella Fortini (2017). Overcoming challenges in the diagnosis of Schistosoma mansoni infections using POC tests, recombinant protein and monoclonal antibody technology Faseb Journal .
Shollenberger, L. (2017). Vaccine self-assembling immune matrix is a non-viral delivery platform that improves overall vaccine performance while maintaining safety and stability Journal of Immunology.
Shollenberger, L. (2015). Enhancing immunogenicity of recombinant protein vaccines in mice with vaccine self-assembling immune matrix, a non-viral delivery platform Journal of Immunology.
Shollenberger, L. (2014). Vaccine self-assembling immune matrix (VacSIM) is a non-viral delivery platform that augments responses to recombinant protein vaccines Journal of Immunology.
Samli, E. Farah. (2014). VacSIM (TM) - a new delivery method increases influenza vaccine efficacy Journal of Immunology.
McEwen, L. (2012). Driving HIV-specific vaccine responses in immune suppressed recipients Journal of Immunology.
McEwen, L. (2011). Driving HIV-1 specific responses in immune suppressed recipients: Listeria as a vaccine vector Journal of Immunology.
Queiroz, R. (2011). New vaccination delivery regimen drives enhanced, vaccine-specific immune responses. Journal of Immunology.
Shollenberger, L. (2006). Interaction of LPD Nanoparticles with Dendritic Cells (pp. S412-S412) Molecular Therapy.
Liu, F. (2006). Mechanism of Naked DNA Clearance after Intravenous Injection (pp. S412-S413) Molecular Therapy.

Presentations

Shollenberger, L. (May 21, 2019). Overcoming Vaccine Failure Keynote/Plenary Address Research Symposium and 78th Annual Meeting .
Shollenberger, L. M. (May 11, 2019). The “Crisis of Reproducibility” of Animal Studies: Causes and Solutions Poster Immunology 2019 San Diego, CA, USA.
Shollenberger, L. (March 3, 2019). Keynote/Plenary Address Induction Ceremony .
Shollenberger, L. M. (October 29, 2018). Immunogenicity and Efficacy of Malarial CelTOS and CSP Vaccine Antigens Administered with Gel-Depot Adjuvant Poster ASTMH18 New Orleans, LA, USA.