Burden of Dengue Infection in Bangladesh: Preliminary Findings of a Systematic Review and Meta-Analysis
Poster #: 169
Session/Time: B
Author:
MD Estiar Rahman, BS, MS
Mentor:
Abdullah Al-Taiar, MD, PhD
Research Type: Review Article
Abstract
INTRODUCTION:
Dengue is endemic in Bangladesh. It is critical to estimate the pooled prevalence to know about the disease burden, which ultimately helps to allocate resources for dengue control. Therefore, this systematic review and meta-analysis aimed to estimate the dengue infection burden in Bangladesh.
METHODS:
Literature search was performed across PubMed, Web of Science, and Hinari between December 2024 and February 2025, with manual searches from references of the retrieved studies. Pooled estimates were calculated using random-effects models due to the heterogeneity of studies and presented in the Forest plots. The analyses were performed by R (version 4.4.3) with 'Meta' package.
RESULTS:
The analysis included 16 of the 776 studies that were identified through database searches. The pooled estimates of dengue prevalence were 49% (95% confidence interval (CI): 33% - 66%; I²: 99.7%) among suspected dengue patients, 52% (95% CI: 0% - 100%; I²: 99.9%) among general population, and 51% (95% CI: 36% - 64%; I²: 99.7%) among general patients. Pooled prevalence estimates were highest in studies conducted in Dhaka city (53%; 95% CI: 39% - 68%; I2:99.7%), and the DENV2 serotype accounted for the highest prevalence at 41%; (95%CI: 17% -64%; I2:98.8%).
CONCLUSION:
This review identified significant heterogeneity among studies, which suggests conducting future research, such as hospital-based or community-based observational studies to generate reliable data about dengue prevalence in Bangladesh.
Dengue is endemic in Bangladesh. It is critical to estimate the pooled prevalence to know about the disease burden, which ultimately helps to allocate resources for dengue control. Therefore, this systematic review and meta-analysis aimed to estimate the dengue infection burden in Bangladesh.
METHODS:
Literature search was performed across PubMed, Web of Science, and Hinari between December 2024 and February 2025, with manual searches from references of the retrieved studies. Pooled estimates were calculated using random-effects models due to the heterogeneity of studies and presented in the Forest plots. The analyses were performed by R (version 4.4.3) with 'Meta' package.
RESULTS:
The analysis included 16 of the 776 studies that were identified through database searches. The pooled estimates of dengue prevalence were 49% (95% confidence interval (CI): 33% - 66%; I²: 99.7%) among suspected dengue patients, 52% (95% CI: 0% - 100%; I²: 99.9%) among general population, and 51% (95% CI: 36% - 64%; I²: 99.7%) among general patients. Pooled prevalence estimates were highest in studies conducted in Dhaka city (53%; 95% CI: 39% - 68%; I2:99.7%), and the DENV2 serotype accounted for the highest prevalence at 41%; (95%CI: 17% -64%; I2:98.8%).
CONCLUSION:
This review identified significant heterogeneity among studies, which suggests conducting future research, such as hospital-based or community-based observational studies to generate reliable data about dengue prevalence in Bangladesh.