Nicola Lai

757-683-6062

231 KAUFMAN HALL
NORFOLK, 23529

Ph.D. in Chemical Engineering, University of Pisa, (2002)

M.S. in Chemical Engineering, University of Cagliari, (1998)

Contracts, Grants and Sponsored Research

Osgood, C. J., Stacey, M. W., Elmustafa, A., Lai, N., Beebe, S. J., Hargrave, B., Zemlin, C. and Xu, X. "Addition of a micro-CT animal scanner to complement and expand current in vivo imaging capabilities" $423,850. Federal. -
Lai, N. "Systems biology investigation of oxidative muscle metabolism by NIR spectroscopy" $593,475. Federal. April 5, 2011 - March 31, 2016
Lai, N. "Systems biology investigation of muscle exercise metabolism in aging and diabetes" $118,695. Federal. April 1, 2014 - April 1, 2015
Lai, N. and Drumm, M. "Translational research in cystic fibrosis" $102,050. Federal. August 2012 - January 2015

Research Interests

Research Interests: Mass transport and metabolism in cell, tissue & organ systemsMathematical modeling & analysis of dynamic and distributed systemSystems Integrated PhysiologyMitochondrial Bioenergetics

Articles

Lai, N., Kummitha, C. and Hoppel, C. (2017). Defects in skeletal muscle subsarcolemmal mitochondria in a non-obese model of type 2 diabetes mellitus. PLOS ONE 12 (8).
Lai, N., Martis, A., Belfiori, A., Tolentino-Silva, F., Nasca, M. M.., Strainic, J. and Cabrera, M. E.. (2016). Gender differences in (V)over dotO(2) and HR kinetics at the onset of moderate and heavy exercise intensity in adolescents. PHYSIOLOGICAL REPORTS 4 (18).
Liu, Y., Mei, X., Li, J., Lai, N. and Yu, X. (2016). Mitochondrial function assessed by P-31 MRS and BOLD MRI in non-obese type 2 diabetic rats. PHYSIOLOGICAL REPORTS 4 (15).
Bederman, I. R.., Lai, N., Shuster, J., Henderson, L., Ewart, S. and Cabrera, M. E.. (2015). Chronic hindlimb suspension unloading markedly decreases turnover rates of skeletal and cardiac muscle proteins and adipose tissue triglycerides. JOURNAL OF APPLIED PHYSIOLOGY 119 (1) , pp. 16-26.
Fealy, C. E., Mulya, A., Lai, N. and Kirwan, J. P. (2014). Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle.. Journal of applied physiology (Bethesda, Md. : 1985) 117 (3) , pp. 239-45.
Criss, C. N., Petro, C. C., Krpata, D. M., Seafler, C. M., Lai, N., Fiutem, J., Novitsky, Y. W. and Rosen, M. J. (2014). Functional abdominal wall reconstruction improves core physiology and quality-of-life.. Surgery 156 (1) , pp. 176-82.
Spires, J., Gladden, L. Bruce., Grassi, B., Goodwin, M. L.., Saidel, G. M.. and Lai, N. (2013). Distinguishing the effects of convective and diffusive O-2 delivery on (V) over dotO(2) on-kinetics in skeletal muscle contracting at moderate intensity. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 305 (5) , pp. R512-R521.
Coskun, S. A., Cicek, A. E., Lai, N., Dash, R. K., Ozsoyoglu, M. and Ozsoyoglu, G. (2013). An online model composition tool for system biology models.. BMC systems biology 7 , pp. 88.
Spires, J., Gladden, L. B., Grassi, B., Goodwin, M. L., Saidel, G. M. and Lai, N. (2013). Distinguishing the effects of convective and diffusive O₂ delivery on VO₂ on-kinetics in skeletal muscle contracting at moderate intensity.. American journal of physiology. Regulatory, integrative and comparative physiology 305 (5) , pp. R512-21.
Goodwin, M. L.., Hernandez, A., Lai, N., Cabrera, M. E.. and Gladden, L. Bruce. (2012). (V) over dotO(2) on-kinetics in isolated canine muscle in situ during slowed convective O-2 delivery. JOURNAL OF APPLIED PHYSIOLOGY 112 (1) , pp. 9-19.
Li, Y., Lai, N., Kirwan, J. P.. and Saidel, G. M.. (2012). Computational Model of Cellular Metabolic Dynamics in Skeletal Muscle Fibers During Moderate Intensity Exercise. CELLULAR AND MOLECULAR BIOENGINEERING 5 (1) , pp. 92-112.
Lai, N., Tolentino-Silva, F., Nasca, M. M.., Silva, M. A.., Gladden, L. Bruce. and Cabrera, M. E.. (2012). Exercise intensity and oxygen uptake kinetics in African-American and Caucasian women. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 112 (3) , pp. 973-982.
Spires, J., Gladden, L. B., Grassi, B., Saidel, G. M. and Lai, N. (2012). Model analysis of the relationship between intracellular PO2 and energy demand in skeletal muscle.. American journal of physiology. Regulatory, integrative and comparative physiology 303 (11) , pp. R1110-26.
Coskun, S. A., Qi, X., Cakmak, A., Cheng, E., Cicek, A. E., Yang, L., Jadeja, R., Dash, R. K., Lai, N., Ozsoyoglu, G. and Ozsoyoglu, M. (2012). PathCase-SB: integrating data sources and providing tools for systems biology research.. BMC systems biology 6 (1) , pp. 67.
Li , Y., Lai, N., Kirwan, J. P. and Saidel, G. M. (2012). Computational Model of Cellular Metabolic Dynamics in Skeletal Muscle Fibers during Moderate Intensity Exercise.. Cellular and molecular bioengineering 5 (1) , pp. 92-112.
Lai, N., Tolentino-Silva, F., Nasca, M. M., Silva, M. A., Gladden, L. B. and Cabrera, M. E. (2012). Exercise intensity and oxygen uptake kinetics in African-American and Caucasian women.. European journal of applied physiology 112 (3) , pp. 973-82.
Goodwin, M. L., Hernández, A., Lai, N., Cabrera, M. E. and Gladden, L. B. (2012). VO(2) on-kinetics in isolated canine muscle in situ during slowed convective O(2) delivery.. Journal of applied physiology (Bethesda, Md. : 1985) 112 (1) , pp. 9-19.
Cakmak, A., Qi, X., Coskun, S. A., Das, M., Cheng, E., Cicek, A. E., Lai, N., Ozsoyoglu, G. and Ozsoyoglu, M. (2011). PathCase-SB architecture and database design.. BMC systems biology 5 , pp. 188.
Spires, J., Lai, N., Zhou, H. and Saidel, G. M. (2011). Hemoglobin and myoglobin contributions to skeletal muscle oxygenation in response to exercise.. Advances in experimental medicine and biology 701 , pp. 347-52.
Coskun, S., Cheng, E., Qi, X., Jadeja, R., Cicek, E., Syed, S., Bai, Z., Lai, N., Dash, R., Ozsoyoglu, G. and others (2010). PathCase SysBio: Database-Enabled Tools for Regulatory Metabolic Networks. Ohio Collaborative Conference on Bioinformatics.
Hernández, A., McDonald, J. R., Lai, N. and Gladden, L. B. (2010). A prior bout of contractions speeds VO2 and blood flow on-kinetics and reduces the VO2 slow-component amplitude in canine skeletal muscle contracting in situ.. Journal of applied physiology (Bethesda, Md. : 1985) 108 (5) , pp. 1169-76.
Hernández, A., Goodwin, M. L., Lai, N., Cabrera, M. E., McDonald, J. R. and Gladden, L. B. (2010). Contraction-by-contraction VO2 and computer-controlled pump perfusion as novel techniques to study skeletal muscle metabolism in situ.. Journal of applied physiology (Bethesda, Md. : 1985) 108 (3) , pp. 705-12.
Lai, N., Zhou, H., Saidel, G. M., Wolf, M., McCully, K., Gladden, L. B. and Cabrera, M. E. (2009). Modeling oxygenation in venous blood and skeletal muscle in response to exercise using near-infrared spectroscopy.. Journal of applied physiology (Bethesda, Md. : 1985) 106 (6) , pp. 1858-74.
Zhou, H., Lai, N., Saidel, G. M. and Cabrera, M. E. (2009). Multiscale modeling of respiration.. IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 28 (3) , pp. 34-40.
Lai, N., Saidel, G. M., Iorio, M. and Cabrera, M. E. (2009). Non-invasive estimation of metabolic flux and blood flow in working muscle: effect of blood-tissue distribution.. Advances in experimental medicine and biology 645 , pp. 155-60.
Zhou, H., Lai, N., Saidel, G. M. and Cabrera, M. E. (2008). Multi-scale model of O2 transport and metabolism: response to exercise.. Annals of the New York Academy of Sciences 1123 , pp. 178-86.
Lai, N., Nasca, M. M., Silva, M. A., Silva, F. T., Whipp, B. J. and Cabrera, M. E. (2008). Influence of exercise intensity on pulmonary oxygen uptake kinetics at the onset of exercise and recovery in male adolescents.. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 33 (1) , pp. 107-17.
Lai, N., Gladden, L. B., Carlier, P. G. and Cabrera, M. E. (2008). Models of muscle contraction and energetics.. Drug discovery today. Disease models 5 (4) , pp. 273-288.
Lai, N., Syed, N., Saidel, G. M. and Cabrera, M. E. (2008). Muscle oxygen uptake differs from consumption dynamics during transients in exercise.. Advances in experimental medicine and biology 614 , pp. 325-32.
Lai, N., Saidel, G. M., Grassi, B., Gladden, L. B. and Cabrera, M. E. (2007). Model of oxygen transport and metabolism predicts effect of hyperoxia on canine muscle oxygen uptake dynamics.. Journal of applied physiology (Bethesda, Md. : 1985) 103 (4) , pp. 1366-78.
Lai, N., Camesasca, M., Saidel, G. M., Dash, R. K. and Cabrera, M. E. (2007). Linking pulmonary oxygen uptake, muscle oxygen utilization and cellular metabolism during exercise.. Annals of biomedical engineering 35 (6) , pp. 956-69.
Pisu, M., Lai, N., Concas, A. and Cao, G. (2006). A novel simulation model for engineered cartilage growth in static systems.. Tissue engineering 12 (8) , pp. 2311-20.
Mameli, A., Cincotti, A., Lai, N., Crisafulli, C., Sciré, S. and Cao, G. (2004). Adsorption of organic compounds onto activated carbons from recycled vegetables biomass.. Annali di chimica 94 (7-8) , pp. 547-54.

Conference Proceeding

Lai, N., Pfaff, N., Fiutem, J. J.., Shivapour, J., Strainic, J. and Grassi, B. (2016). Gender Differences In The Cardiorespiratory Response To Exercise Using A Modified Bruce Protocol In Children (pp. 1023-1023) MEDICINE AND SCIENCE IN SPORTS AND EXERCISE.

Presentations

Lai, N. (November , 2013). Computational modeling and analysis of integrated cellular and tissue-organ responses to physiological stimuli. Lecture Department of Mathematical Sciences, University of Nevada, Las Vegas.
Lai, N. (September , 2012). Central and peripheral factors affecting oxidative metabolism in pediatric populations in healthy and disease states Lecture Rainbow Babies and Children's Hospital.
Lai, N. (September , 2012). Energy metabolism in cystic fibrosis Other .
Lai, N. (August , 2012). Integrating computational and experimental approaches to study oxygen transport and energy metabolism in contracting muscle Oral Presentation Systems Biology of Exercise Conference Leeds.
Lai, N. (December , 2010). A systems biology approach to study metabolic regulation in tissue/organ systems in health and disease states Lecture Polaris - Science and Technology Park of Sardinia.
Lai, N. (December , 2010). Factors regulating fat metabolism during exercise: role of adipose tissue and skeletal muscle Lecture .
Lai, N. (December , 2009). Modelli Sperimentali e Computazionali per lo studio della dinamica di trasporto dell’ossigeno e del metabolismo ossidativo del sistema muscolo-scheletrico Lecture Department of Material Science and Chemical Engineering .
Lai, N. (December , 2009). Studio del metabolismo energetico muscolare: approccio sperimentale e modellistico computazionale Lecture Department of Material Science and Chemical Engineering .
Lai, N. (June , 2009). Integrated systems physiology to study muscle energy metabolism Lecture Groupe Hospitalier Pitié-Salpêtrière, France.
  • 2007: Duane F. Bruley Award, International Society on Oxygen Transport to Tissue (ISOTT)

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