Christopher Osgood

Ph.D. in Biology, Brown University, (1977)

B.A. in Human Biology, Brown University, (1971)

Articles

Baldwin, W., Gregory, B., Osgood, C. J., Schoenbach, K. H. and Kolb, J. (2010). Using Ionized Gases and Electromagnetic Fields Special Issue—Nonthermal Medical/Biological Applications Membrane Permeability and Cell Survival After Nanosecond Pulsed-Electric-Field Exposure—Significance of Exposure-Media Composition. IEEE Transactions on Plasma Science 38 (10) , pp. 2948.

Osgood, C. J. and Seward, S. (1989). The use of molecularly tagged P elements to monitor spontaneous and induced frequencies of transposon excision and transposition. Progress in nucleic acid research and molecular biology 36 , pp. 59–67.

Zimmering, S. and Osgood, C. J. (1975). Preliminary evidence of the influence of caffeine concentration on modification of maternal repair of chromosome breaks induced by X-rays in the paternal genome of Drosophila. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 30 (2) , pp. 289–291.

Ramadan, E., Ward, M., Guo, X., Durkin, S. S., Sawyer, A., Vilela, M., Osgood, C. J., Pothen, A. and Semmes, O. J. (2008). Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome. Retrovirology 5 (92).

Osgood, C. J. and Zimmering, S. (1972). Measurement of radiation-induced dominant lethals in stage-14 oocytes of Drosophila. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 15 (3) , pp. 355–357.

Osgood, C. J. and Sterling, D. (1991). Dichloroacetonitrile, a by-product of water chlorination, induces aneuploidy in Drosophila. Mutation Research 261 (2) , pp. 85–91.

Zimmering, S., Mason, J. and Osgood, C. J. (1986). Current status of aneuploidy testing in Drosophila. Mutation Research 167 (1-2) , pp. 71–87.

Osgood, C. J. and Sterling, D. (1991). Chrysotile and amosite asbestos induce germ-line aneuploidy in Drosophila. Mutation Research 261 (1) , pp. 9–13.

Sehgal, A., Osgood, C. J., Zimmering, S. and Aaron, C. (1990). Aneuploidy in drosophila. III: Aneuploidogens inhibit in vitro assembly of taxol-purified drosophila microtubules. Environmental and molecular mutagenesis 16 (4) , pp. 217–224.

Osgood, C. J., Zimmering, S. and Mason, J. (1991). Aneuploidy in Drosophila, II. Further validation of the FIX and ZESTE genetic test systems employing female Drosophila melanogaster. Mutation Research 259 (2) , pp. 147–163.

Zimmering, S., Osgood, C. J. and Mason, J. (1990). Aneuploidy in Drosophila, I. Genetic test systems in the female Drosophila melanogaster for the rapid detection of chemically induced chromosome gain and chromosome loss. Mutation Research/Environmental Mutagenesis and Related Subjects 234 (5) , pp. 319–326.

Kooistra, R., Vreeken, K., Zonneveld, J. B., de Jong, A., Eeken, J. C., Osgood, C. J., Buerstedde, J. M., Lohman, P. H. and Pastink, A. (1997). The Drosophila melanogaster RAD54 homolog, DmRAD54, is involved in the repair of radiation damage and recombination. Molecular and cellular biology 17 (10) , pp. 6097-104.

Osgood, C. J. and Lacy, L. R. (1986). Tests for chemical-induced germline transposition in Drosophila melanogaster. Progress in clinical and biological research 209B , pp. 399-409.

Thompson, D. M., Khalil, S. M., Jeffers, L. A., Sonenshine, D., Mitchell, R., Osgood, C. J. and Michael Roe, R. (2007). Sequence and the developmental and tissue-specific regulation of the first complete vitellogenin messenger RNA from ticks responsible for heme sequestration. Insect biochemistry and molecular biology 37 (4) , pp. 363-74.

Osgood, C. J. (1994). Refractory ceramic fibers (RCFs) induce germline aneuploidy in Drosophila oocytes. Mutation research 324 (1-2) , pp. 23-7.

Lacy, L. R., Eisenberg, M. T. and Osgood, C. J. (1986). Molecular analysis of chemically-induced mutations at the RpII215 locus of Drosophila melanogaster. Mutation research 162 (1) , pp. 47-54.

Osgood, C. J. and Cyr, K. (1998). Induction by nitriles of sex chromosome aneuploidy: tests of mechanism. Mutation research 403 (1-2) , pp. 149-57.

Thompson, D. M., Khalil, S. M., Jeffers, L. A., Ananthapadmanaban, U., Sonenshine, D., Mitchell, R., Osgood, C. J., Apperson, C. S. and Michael Roe, R. (2005). In vivo role of 20-hydroxyecdysone in the regulation of the vitellogenin mRNA and egg development in the American dog tick, Dermacentor variabilis (Say). Journal of insect physiology 51 (10) , pp. 1105-16.

Basu, G., Kalluri, B. S., Sabuncu, A. C., Osgood, C. J. and Stacey, M. W. (2012). Enhanced killing effect of nanosecond pulse electric fields on PANC1 and Jurkat cell lines in the presence of Tween 80. The Journal of membrane biology 245 (10) , pp. 611-6.

Muris, D. F., Bezzubova, O., Buerstedde, J. M., Vreeken, K., Balajee, A. S., Osgood, C. J., Troelstra, C., Hoeijmakers, J. H., Ostermann, K. and Schmidt, H. (1994). Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination. Mutation research 315 (3) , pp. 295-305.

Osgood, C. J. and Boyd, J. B. (1982). Apurinic endonuclease from Drosophila melanogaster: reduced enzymatic activity in excision-deficient mutants of the mei-9 and mus(2)201 Loci. Molecular & general genetics 186 (2) , pp. 235-9.

Pfeffer, J., Pang, M. G., Hoegerman, S. F., Osgood, C. J., Stacey, M. W., Mayer, J., Oehninger, S. and Kearns, W. G. (1999). Aneuploidy frequencies in semen fractions from ten oligoasthenoteratozoospermic patients donating sperm for intracytoplasmic sperm injection. Fertility and sterility 72 (3) , pp. 472-8.

Osgood, C. J. and Seward, S. M. (1989). 5-Azacytidine induces sex chromosome loss and interchange in immature germ cells of Drosophila mei-9 males. Environmental and molecular mutagenesis 14 (3) , pp. 135-45.

Tiangco, D. A., Lattanzio, Jr, F. A., Osgood, C. J., Beebe, S. J., Kerry, J. A. and Hargrave, B. (2005). 3,4-Methylenedioxymethamphetamine activates nuclear factor-kappaB, increases intracellular calcium, and modulates gene transcription in rat heart cells. Cardiovascular toxicology 5 (3) , pp. 301-10.

Zimmering, S., Kolkoff, R. and Osgood, C. J. (1977). Survival of caffeine-fed adult males and females from strains of Drosophila melanogaster. Mutation Research 43 (3) , pp. 453-6.

Osgood, C. J. and Zimmering, S. (1979). Effects of caffeine on maternal repair systems in Drosophila melanogasgter. Concentration-dependent reversals of the effects of caffeine on chromosome loss and autosome-autosome translocations induced by x-rays in the paternal genome. Mutation Research 63 (1) , pp. 79-86.

Osgood, C. J. and Zimmering, S. (1980). Evidence for an increase in X-ray-ray-induced translocation frequency in oocytes of caffeine-treated Drosophila females. Mutation Research 71 (2) , pp. 207-10.

Boyd, J. B., Golino, M. D., Shaw, K. E., Osgood, C. J. and Green, M. M. (1981). Third-chromosome mutagen-sensitive mutants of Drosophila melanogater. Genetics 97 (3-4) , pp. 607-23.

Zhang, W., Li, R., Feng, D., Chernikov, A., Chrisochoides, N., Osgood, C. J. and Ji, S. (2015). Evolutionary Soft Co-Clustering Formulations, Algorithms and Applications. Data Mining and Knowledge Discovery, Springer 29 (3) , pp. 765-791.

Whelan, E., Nwala, A. C., Osgood, C. J. and Olariu, S. (2016). Selective mutation accumulation: A computational model of paternal age effect. Bioinformatics 32 (24) , pp. 3790–3797.

Mahadevan, K., Patthipati, V. S., Han, S., Swanson, R. J., Whelan, E., Osgood, C. J. and Ramjee, B. (2016). Highly fluorescent resorcinarene cavitand nanocapsules with efficient renal clearance. Nanotechnology 27 (33).

Aridgides, L. J., Stacey, M. W., Brihn, L., Scott, D. and Osgood, C. J. (2002). Fluorescence in situ hybridization on sperm using alkaline denaturation. Biotechniques 33 (2) , pp. 266-7.

Stacey, M. W., Osgood, C. J., Kalluri, B. S., Cao, W., Elsayed-Ali, H. and Fattah, T. Abdel. (2011). Nanosecond pulse electrical fields used in conjunction with multi-wall carbon nanotudes as a potential tumor treatment. Biomed Mater 6 (1) , pp. 011002.

Ding, F., Lee, K. J ., Vahedi-Farid, A., Yoneyama, H., Osgood, C. J. and Xu, X. Nancy. (2014). Design and study of efflux function of EFGP fused MexAB-OprM membrane transporter in Pseudomonas aeruginosa. Analyst 139 , pp. 3088-3096.

Lee, K. J., Browning, L. B., Nallathamby, P., Osgood, C. J. and Xu, X. Nancy. (2013). Silver Nanoparticles Induce Developmental Stage-Specific Embryonic Phenotypes in Zebrafish. Nanoscale 5 (23) , pp. 11625-36.

Zhang, W., Feng, D., Li, R., Chernikov, A., Chrisochoides, N., Osgood, C. J. and Ji, S. (2013). A mesh generation and machine learning framework for. BMC Bioinformatics 14 , pp. 372.

Lee, K. J.., Nallathamby, P. D.., Browning, L., Osgood, C. J. and Xu, X. Nancy. (2007). In vivo imaging of transport and biocompatibility of single silver nanoparticles in early development of zebrafish embryos. ACS Nano 1 (2) , pp. 133-143.

Osgood, C. J., Nuccitelli, R., Chen, X., Pakhomov, A. G., Baldwin, W. H., Sheikh, S., Pomicter, J. L., Swanson, R. J., Kolb, J. F., Beebe, S. J. and Schoenbach, K. H. (2009). A new pulsed electric field therapy for melanoma disrupts tumor's blood supply and causes complete remission without recurrence. International journal of cancer 125 (2) , pp. 438-445.

Baldwin, W. H., Gregory, B. W., Osgood, C. J., Schoenbach, K. H. and Kolb, J. F. (2010). Membrane permeability and cell survival after nanosecond pulsed electric field exposure -- significance of exposure media composition. IEEE.

Thompson, D. M., Sayed, M., Khalil, S., Jeffers, L. A., Sonenshine, D. E., Mitchell, R. D., Osgood, C. J. and Roe, M. R. (2007). Sequence and the developmental and tissue-specific regulation of the first vitellogenin messenger RNA from ticks responsible for heme sequestration. Insect Biochem Molec Biol , pp. 10.1016/j.ibmb.2007.01.004.

Mitchell, R. D., Ross, E., Osgood, C. J., Sonenshine, D. E., Donohue, K. V., Khalil, S. M., Thompson, M. and Roe, M. (2007). Molecular characterization, tissue-specific expression and RNAi knockdown of the first vitellogenin receptor from a tick. Insect Biochem Molec Biol , pp. 10.1016/j.ibmb.2007.01.005.

Osgood, C. J., Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Nuccitelli, R., Pakhomov, A., Stacey, M. W., Swanson, R. J., White, J., Xiao, S. and Zhang, J. (2007). Bioelectric effects of intense nanosecond pulses. IEEE Transactions on Dielectrics and Electrical Insulation 14 (5) , pp. 1088-1109.

Osgood, C. J., Lattanzio, F. A., Tiangco, D., Beebe, S., Kerry, J. and Hargrave, B. (2005). Cocaine increases intracellular calcium and reactive oxygen species, depolarizes, mitochondria and activates genes associated with heart failure and remodeling. Cardiovasc Toxicol 5 (4) , pp. 377-390.

Yamaguchi, H., Aridgides, L. J., Zeng, W., Osgood, C. J., Young, N. S. and Liu, J. M. (2003). Genetic and transcriptional analysis of spindle checkpoint genes in bone marrow failure patients. Blood Cells Mol Dis 30 (3) , pp. 307-311.

Books

Osgood, C. J. (1988). NIEHS 55106: Aneuploidy Testing in Drosophila. Old Dominion University. Department of Biological Sciences.

Osgood, C. J. (1986). Chemically-induced Transposition in Drosophila. Old Dominion University Research Foundation.

Osgood, C. J. (1987). Aneuploidy Testing in Drosophila. Old Dominion University Research Foundation.

Book Chapters

Boyd, J. B., Harris, P. V., Osgood, C. J. and Smith, K. E. (1980). Biochemical characterization of repair-deficient mutants of Drosophila DNA Repair and Mutagenesis in Eukaryotes (pp. 209-21) Basic Life Sciences.

Conference Proceeding

Durbin, J., Stacey, M. W. and Osgood, C. J. (2018). Plastinates in the anatomy lab: a safe alternative to formalin fixed tisue no ISBio Tech Spring Conference for Bioprocessing Technologies - Poster.

Osgood, C. J., Blanchfield, L., Slotnick, R., Stacey, M. W., Gabriel, C. and Lidwell, D. (2002). Paternal origin of Y-chromosome-bearing cells in microchimeric nulligravid females with autoimmune disease (pp. 491–491) American Journal of Human Genetics .

Kolb, J., Scarlett, S., Cannone, J., Zhuang, J., Osgood, C. J., Schoenbach, K. H., de Angelis, A. and Zeni, L. (2008). Nanosecond pulse generator with variable pulse duration for the study of pulse induced biological effects IEEE International Power Modulators and High Voltage Conference, Proceedings of the 2008 (pp. 61–64).

Slotnick, R., Atkins, K., Leung, J., Warren, A., Blanchfield, L., Stacey, M. W., Gabriel, C. and Osgood, C. J. (2001). Microchimerism for Y-chromosome bearing cells in nulligravid females presenting with pediatric autoimmune disease. AMERICAN JOURNAL OF HUMAN GENETICS (pp. 663–663).

Stacey, M. W., McAninch, T., Santi, L., Osgood, C. J., Byrd, R., Liu, J., Young, N. and Kearns, W. (1999). Increased frequency of glutathione-S transferase (GSTT1) null genotype in patients with aplastic anemia and myelodysplastic syndromes. AMERICAN JOURNAL OF HUMAN GENETICS (pp. A324–A324).

Stacey, M. W., Mcaninch, T., Santi, L., Clarey, M., Osgood, C. J., Byrd, R., Liu, J., Young, N. and Kearns, W. (1999). Glutathione-S transferase (GSTT1 and GSTM1) null genotypes in patients with aplastic anemia and myelodysplastic syndromes Blood (pp. 675A–675A).

Osgood, C. J., Spivey, A., Stacey, M. W. and Kim, A. (2001). Glutathione S-transferase theta and mu (GSTM1 and GSTT1) gene expression in patients with aplastic anemia and myelodysplastic syndrome. AMERICAN JOURNAL OF HUMAN GENETICS (pp. 250–250).

Kearns, W., Liu, J., Aridgides, L., Stacey, M. W., Osgood, C. J., Byrd, R., Saunthararajah, Y., Maciejewski, J., Saunthararajah, Y. and Young, N. (1999). Genomic instability in bone marrow failure syndromes: High frequency of aneuploidy by fluorescence in situ hybridization and identification of a spindle checkpoint gene mutation. Blood (pp. 674A–674A).

Osgood, C. J. and Boyd, J. (1979). DROSOPHILA DNA-REPAIR ENDONUCLEASE SPECIFIC FOR APURINIC-APYRIMIDINIC SITES IN DNA Genetics (pp. S91–S92).

Ramadan, E., Osgood, C. J. and Pothen, A. (2010). Discovering overlapping modules and bridge proteins in proteomic networks Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology (pp. 366–369).

Schoenbach, K. H., Katsuki, S., Akiyama, H., Heeren, T., Kolb, J., Xiao, S., Camp, T., Joshi, R., Osgood, C. J., Nuccitelli, R. and others (2006). Biological effects of intense subnanosecond electrical pulses Power Modulator Symposium, 2006. Conference Record of the 2006 Twenty-Seventh International (pp. 573–576).

Pang, M., Hoegerman, S., Pfeffer, J., Stacey, M. W., Lunsford, L., Osgood, C. J., Donsel, G., Oehninger, S., Acosta, A. and Kearns, W. (1999). Aneuploidy in sperm from fifty-four oligoasthenoteratozoospermic patients undergoing intracytoplasmic sperm injection. AMERICAN JOURNAL OF HUMAN GENETICS (pp. A353–A353).

Xu, X. Nancy., Gillet, D., Elsayed-Ali, H., Osgood, C. J. and Van Duyne, R. (2006). NIRT (II): Design of biocompatible nanoparticles for probing living cellular functions and their potential environmental impacts NSF NIRT Grantee Conference (NSF).

Xu, X. Nancy., Gillet, D., Elsayed-Ali, H., Osgood, C. J. and Van Duyne, R. (2005). NIRT (I): Design of biocompatible nanoparticles for probing living cellular functions and their potential environmental impacts NSF NIRT Grantee Conference (NSF).

Maly, K. J., Pothen, A., Zubair, M., Osgood, C. J. and Semmes, O. J. (2006). A prototype of the HumanVirus Interactome Resource (HVIR) (pp. 172-180) Vladimir: RCDL.

Ramadan, E., Osgood, C. J. and Pothen, A. (2005). The architecture of a proteomic network in the Yeast (pp. 265-276) CompLife'05 Proceedings of the First international conference on Computational Life Sciences.

Presentations

Schoenbach, K. H., Katsuki, S., Akiyama, H., Heeren, T., Kolb, J. F., Xiao, S., Camp, T., Joshi, R., Osgood, C. J., Nuccitelli, R. and Beebe, S. J. (May , 2006). Biological Effects of Intense Subnanosecond Electrical Pulses Conf. Record of the 2006 IEEE Power Modulator Conference Washington DC.

Swanson, R. J., Zhang, Y., Sonenshine, D. E., Osgood, C. J., Beebe, S. J. and Schoenbach, K. H. (August , 2008). Hatching and death rates of nematode Caenorhabditis elegans post-nanosecond pulsed electric fields (nsPEF) 1st International Conference for Invertebrate Morphology Copenhagen, Denmark.

Whelan, E., Stacey, M. W. and Osgood, C. J. (May 15, 2014). Positive selection of spermatogonial stem cells Oral Presentation Virginia Academy of Sciences VCU Richmond VA.

Bani Hani, M., Stacey, M. W. and Osgood, C. J. (May 15, 2014). Interactions between nanoparticles and macrophage Oral Presentation Virginia Academy of Sciences VCU, Richmond VA.

Osgood, C. J. and Landers, A. (May 21, 2014). Improving Disciplinary Writing Through Action Projects - W course improvement in the COS Oral Presentation CLT Faculty Summer Institute, 2014 Norfolk, VA.

Ngabonziza, S., Osgood, C. J. and Swanson, R. J. (October 24, 2014). In vivo nanosecond electric stimuli for non-lethal immobilization in fully conscious rats Poster Hampton Roads Neuroscience Network Norfolk, VA.

Holland, C. A. and Osgood, C. J. (February 7, 2015). Investigating nanocapsule uptake in neural immune cells Poster ODU Undergraduate Research Symposium Norfolk, VA.

Bani Hani, M. and Osgood, C. J. (May 19, 2016). Response of Immune Cells to Nanodiamonds in vitro Oral Presentation Virginia Academy of Sciences 94th Annual Meeting Fredericksburg, VA.

Whelan, E., Osgood, C. J. and Olariu, S. (June 15, 2016). Selective Mutation Accumulation: A Computational Model of the Paternal Age Effect Oral Presentation Germline Stem Cells San Francisco CA.

Whelan, E., Stacey, M. W. and Osgood, C. J. (June 18, 2016). Germline Stem Cells Oral Presentation International Society for Stem Cell Research San Francisco CA.

Bani Hani, M. and Osgood, C. J. (May 18, 2017). Effects of nanodiamonds on bone marrow-derived macrophages, pre- and post-treatment Oral Presentation Virginia Academy of Science, Annual Meeting VCU, Richmond VA.

Wyckoff, C., Xiao, S., Yang, E. and Osgood, C. J. (May 18, 2017). Effect of microbubbles on mammalian cells Oral Presentation Virginia Academy of Science, Annual Meeting VCU, Richmond VA.

Zamponi, M. and Osgood, C. J. (February 10, 2018). Differential gene expression of chondrocytes on PLGA Scaffolds Oral Presentation ODU Undergraduate Research Symposium ODU.

Ayaz, A., Osgood, C. J. and Stacey, M. W. (February 10, 2018). Differential expression of developmental signaling genes between norma chondrocytes and chondrosarcoma cells Oral Presentation ODU Undergraduate Research Symposium ODU.

• 2019: Outstanding Faculty Mentor of Junior Faculty Award, Dept. of Biological Sciences
• 2018: ODU Shining Star Award, SEES
• 2014: Shining Star Recognition, SEES
• 1996: Most Inspiring Faculty Member, Old Dominion University
• 1977: NIH Postdoctoral Fellowship, University of California, Davis
• 1975: JG Petersen Fellowship for Graduate Study, Brown University