A NOVEL NON-ENZYMATIC GLUCOSE BIOFUEL CELL WITH MOBILE GLUCOSE SENSING

by

Ankit Baingane

M.S. December 2017, University of Maryland, Baltimore County

PhD. August 2020, Old Dominion University

Director: Dr. Gymama Slaughter

Dissertation Defense: Friday, July 10^th, 2020 at 11am

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Abstract:

Glucose concentration level is a critical vital parameter for diabetes management. According to World Health Organization, the number of people with diabetes has risen from 108 million in 1980 to 422 million in 2014. In 2016, an estimated 1.6 million deaths were directly caused by diabetes. Continuous glucose monitoring is the best way to minimize the complications arising from increased glucose levels in the body. In this presentation, we report a novel mobile glucose biosensing system which measure the body glucose concentration and sends the measured data to the end user or medical professionals. This system was developed using a non-enzymatic glucose biofuel cell consisting of a colloidal platinum coated gold microwire (Au-co-Pt) employed as an anode and a platinum coated gas diffusion electrode (GDE) as a cathode in a biofuel cell configuration. The biofuel cell produced maximum open circuit voltage (Voc) of 0.54 V and delivered a maximum short circuit current density (Isc) of 1.6 mA/cm² with a peak power density (Pmax) of 0.226 mW/cm² in the presence of 1 M glucose. When operating on physiologic glucose concentration of 5 mM glucose, a Voc of 0.38 V and an Isc of 0.225 mA/cm² with Pmax of 0.022 mW/cm² was observed.  When operated as a glucose biosensor, the system exhibited a good sensitivity of 0.616 μA mM⁻¹ and linear dependence with a correlation coefficient of 0.995 in with a wide linear dynamic range of 2 mM to 50 mM. For mobile glucose sensing, the blinking frequency of the LED integrated to the biosensor system was monitored and correlated with glucose concentration via an android mobile phone camera application to notified end-user of glucose level via text message. 

Bio:

Ankit Baingane is a PhD candidate in the department of Electrical and Computer engineering. He currently works with Dr. Gymama Slaughter at the Frank Reidy Research Centre. His work focuses on design and development of ultralow power circuits and biosensors. In his dissertation, he focuses on development of implantable glucose biosensor with remote data access and monitoring. Ankit graduated with Master’s in computer engineering from University of Maryland in 2017. His hobbies include cooking and travelling.