Bioelectrics Seminar Series
Frank Reidy Research Center for Bioelectrics Seminar Series
Speaker: Nicola Lai, Ph.D., Professor, Department of Electrical and Computer Engineering, ODU
Biomedical Engineering Institute, ODU
Title: Mitochondrial bioenergetics in a non-obese model of type 2 diabetes mellitus: Experimental and Computational Analysis
When: 9:00 AM, Tuesday, Sept. 27, 2016
Where: 1st floor conference room, IRP II
Abstract: Skeletal muscle metabolic functions, which are vital for maintaining health and quality of life, decline with type 2 diabetes mellitus T2DM) and is accompanied by mitochondrial dysfunction and insulin resistance. The causes leading to skeletal muscle insulin resistance point to an accumulation of lipids that appear to impair insulin-signaling pathway. However, it is not clear whether the lipid accumulation is caused by mitochondria dysfunction rather than an enhanced fatty acid transport and/or overload. In this talk, a systems biology approach to study skeletal muscle energy metabolism in a non-obese model of T2DM will be discussed. To evaluate bioenergetic function in both populations of skeletal muscle mitochondria, oxidative phosphorylation and biochemical assays were used to dissecting and analyzing mitochondrial electron transport chain components. To quantify the regulation of bioenergetic processes and fuel utilization as well as identifying the factors limiting oxidative phosphorylation, mathematical models were used combining biochemical, biophysical and physiological processes. Our new findings do not support a primary role of mitochondria in the pathogenesis of skeletal muscle insulin resistance.
Posted By: Barbara Carroll
Date: Thu Sep 22 16:01:52 EDT 2016