Bioelectrics Seminar Series - Gene Electrotransfer: An Effective Nonviral Approach
Frank Reidy Research Center for Bioelectrics Seminar Series
Speaker: Richard Heller, Ph.D., Professor and Eminent Scholar, Frank Reidy Research Center for Bioelectrics,
<p style="\"margin-left:" 40px;\"=""> School of Medical Diagnostics and Translational Sciences, Old Dominion University
Title: Gene Electrotransfer: An Effective Nonviral Approach for Therapeutic Applications
When: 9:00 AM, Tuesday, April 19, 2016
Where: 1st floor conference room, IRP II
Abstract: Gene therapy has held great promise for effective treatment of a variety of disorders. One of the critical aspects of gene transfer is effective delivery. Electrotransfer of plasmid DNA (GET) can be utilized to control expression of the transgene by manipulating parameters such as pulse width, applied voltage, pulse number and electrode configuration. We have utilized GET for delivering DNA vaccines, accelerating wound healing, inducing reperfusion of ischemic tissue and developing an immune gene transfer approach for the treatment of cancer. The immune gene therapy approach has been translated to the clinic and represents the first-in-human study utilizing in vivo GET. This approach has now been successfully tested in multiple Phase II clinical trials. GET is an effective approach for delivering plasmid DNA and the number of applications has been steadily growing.
Richard Heller 04192016.pdf (133.9 KB)
Posted By: Barbara Carroll
Date: Mon Apr 18 08:40:26 EDT 2016