Bioelectrics Seminar Series - Selective cell killing by nanosecond pulsed electric field

Frank Reidy Research Center for Bioelectrics Seminar Series

Speaker: Andrei Pakhomov, Ph.D.

Frank Reidy Research Center for Bioelectrics, Old Dominion University

Title: Selective cell killing by nanosecond pulsed electric field

When: 9:00 AM, Tuesday, November 1, 2016

Where: 1st floor conference room, IRP II

Abstract: Tumor ablation by nanosecond pulsed electric fields (nsPEF) is an emerging therapeutic modality. Killing cells by nsPEF has been extensively explored in vitro, followed by successful tumor ablation trials in animals and in humans. Several studies suggested that nsPEF might selectively target tumors while sparing healthy tissues. We have introduced a novel high-throughput in vitro nsPEF exposure technique and compared nsPEF susceptibility in diverse cell types under strict and uniform experimental conditions. We revealed nearly 80-fold difference between the most and the least sensitive cell lines. However nsPEF was not selective against cancer cells, and its efficacy showed no apparent correlation with cell size, morphology, or tested physiological variables.

A Pakhomov 110116.pdf  (95.2 KB)

Posted By: Barbara Carroll
Date: Mon Oct 31 09:54:13 EDT 2016