Research Assoc Professor
Frank Reidy Research Center for Bioelectrics

Siqi Guo

NORFOLK, 23529

M.D. in Clinical Medicine, Zhejiang University, (1991)

Contracts, Grants and Sponsored Research

Guo, S., Beebe, S. J. and Heller, R. "Nanosecond Electric Pulses (NSEPS) As An Ablation-Immunotherapy For Advanced Pancreatic Cancer- A Comparison Study of Tumor Ablation With Nseps And Irreversible Electroporation (Ire)" $102,900. Commercial. April 1, 2016 - June 30, 2017


Oncology, Immunology, Gene transfer
Gene Electrotransfer
Cancer Research, Gene Electrotransfer, Cancer Immunotherapy


edelblute, C. M., Guo, S., Hornef, J., Yang, E., Jiang, C., Schoenbach, K. H. and Heller, R. (2018). Moderate heat application enhances the efficacy of nanosecond pulse stimulation for the treatment of squamous cell carcinoma. Technology in Cancer Research & Treatment (17) , pp. 1-9.
Lassiter, B. P., Guo, S. and Beebe, S. J. (2018). Nano-pulse stimulation ablates orthotopic rat hepatocellular carcinoma and induces innate and adaptive memory immune mechanisms that prevent recurrence. Cancers 10 (3) , pp. 1-9.
Guo, S., Israel, A. L., Basu, G., Donate, A. and Heller, R. (2013). Topical gene electrotransfer to the epidermis of hairless guinea pig by non-invasive multielectrode array. PLoS One 8 (8) , pp. e73423.
Cobb, D., Guo, S. and Smeltz, R. B.. (2013). CpG and interleukin-15 synergize to enhance IFN-gamma production by activated CD8+ T cells. BioMed research international 2013 , pp. 924023.
Warren, D., Das, S., Guo, S., Xu, J., Kappes,, J. C. and Hel, Z. (2013). Optimization of the transductional efficiency of lentiviral vectors: effect of sera and polycations. Molecular biotechnology 53 (3) , pp. 308-14.
Yang, L., Nyalwidhe, J. O., Guo, S., Drake, R. R. and Semmes, O. John. (2011). Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer. Molecular & cellular proteomics 10 (6) , pp. M110 007294.
Xiao, S., Guo, S., Nesin, V., Heller, R. and Schoenbach, K. H. (2011). Subnanosecond electric pulses cause membrane permeabilization and cell death. IEEE transactions on bio-medical engineering 58 (5) , pp. 1239-45.
Guo, S., Donate , A., Basu, G., Lundberg, C., Heller, L. and Heller, R. (2011). Electro-gene transfer to skin using a noninvasive multielectrode array. Journal of controlled release 151 (3) , pp. 256-62.
Denning, W. L., Xu, J., Guo, S., Klug, C. A. and Hel, Z. (2011). Limited transplantation of antigen-expressing hematopoietic stem cells induces long-lasting cytotoxic T cell responses. PLoS One 6 (2) , pp. e16897.

Conference Proceeding

Heller, R., Shirley, S., Guo, S., Donate, A. and Heller, L. (2012). Electroporation based gene therapy--from the bench to the bedside (pp. 736-8) Annual International Conference of the IEEE Engineering in Medicine and Biology Society.