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- Lesley Greene
- Associate Professor
- Department of Chemistry & Biochemistry
- 202 Alfriend Chemistry Bldg
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Norfolk,
VA
23529
- 757-683-6596
- lgreene@odu.edu
- Web Page
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Education
- University Of Miami,
1998
- Major: Biochemistry
- Degree: Ph. D.
- University of Miami,
1991
- Major: Microbiology
- Degree: B.S.
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Research Interests
- 1. Protein Chemistry: Expression, purification and in vitro refolding of recombinant proteins.
2. Molecular Biology: Cloning and site-directed mutagenesis.
3. Bioinformatics: Sequence, Structural & Evolutionary Analysis; Database Development.
4. Computational Biology: Networks, Molecular Dynamics Simulations & Molecular Modeling.
5. Biophysics: Multidimensional heteronuclear NMR, Real-time 1D NMR & Photo-CIDNP, Circular dichroism & Fluorescence spectroscopy
(equilibrium & stopped flow); Quenched flow HX.
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Book Chapters
- Gaforina, L., Sanchez, D., Greene, L. H., and Flower, D. R. (2006). The lipocalin protein family: Protein sequence and structure. In: Lipocalins.. Georgetown, TX: Landes Biosciences and Eurekha.com.
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Articles
- Li, H., and Greene, L. H. (2010). Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. PLoS One, 13, (pp. e8654).
- Li, H., Wojtaszek, J., and Greene, L. H. (2009). Analysis of conservation in the Fas-associated death domain protein and the importance of conserved tryptophans in structure,
stability, and folding. Biochmica et Biophysica Acta - Proteins & Proteomics, 1794, (pp. 583-593).
- Higman, V. A., Rosner, H. I., Ugolini, R., Greene, L. H., Redfield, C., and Smith, L. J. (2009). Probing the urea dependence of nonrandom interactions in denatured human α-lactalbumin. J. Biomolecular NMR, 45, (pp. 121-131).
- Cuff, A., Redfern, O. C., Greene, L. H., Sillitoe, I., Lewis, T., Dibley, M., Reid, A., Pearl, F., Dallman, T., Todd, A., Garratt, R., Thornton, J., and Orengo, C. (2009). The CATH hierarchy revisited - structural divergence in domain superfamilies and the continuity of fold space. Structure, 17, (pp. 1051-1062).
- Greene, L. H., Lewis, T. E., Addou, S., Cuff, A., Dallman, T., Dibley, M., Redfern, O., Pearl, F., Nambudiry, R., Reid, A., Sillitoe, L., Yeats, C., Thornton, J. M., and Orengo, C. A. (2007). The CATh domain structure database: new protocols and classification levels give a more comprehensive resource for exploring
evolution. Nucleic Acids Research, 35, (pp. D291-D297).
- Greene, L. H., Wijesinha-Bettoni, R., and Redfield, C. (2006). Characterization of the molten globule of human-serum retinol-binding protein by NMR spectroscopy. Biochemistry, 45, (pp. 9475-9484).
- Higman, V. A., and Greene, L. H. (2006). Elucidation of conserved long-range interaction networks in proteins and their significance in determining protein topology. Physica A (pp. 595-606).
- Paci, E., Greene, L. H., Jones, R. M., and Smith, L. J. (2005). Characterization of the molten globule state of retinol-binding protein using a molecular dynamics simulation approach. FEBS J, 272, (pp. 4826-4838).
- Greene, L. H., and Higman, V. A. (2005). Conserved networks and the determinants of protein topology. FEBS J, 272, (pp. Suppl. 1).
- Neerathilingam, M., Greene, L. H., Colebrooke, S. A., Campbell, I. D., and Staunton, D. (2005). Quantitation of protein expression in a cell-free system: Efficient detection of yields and 19F NMR to identify folded protein. J Biomolecular NMR, 31, (pp. 11-19).
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Presentations
- Sponsoring Organization: University of North Carolina
- Location: Greensboro, NC
- Date: November, 2010
- Authors/Presenters:
Greene, L. H.
- Conference Name:
- Location: Norfolk, VA
- Date: June, 2010
- Authors/Presenters:
Greene, L. H.
- Conference Name: ACS
- Sponsoring Organization: ACS
- Location: Washington, DC
- Date: August, 2009
- Authors/Presenters:
Greene, L. H.
- Conserved Protein Structure Networks
- Sponsoring Organization: Winthrop University
- Location: Rock Hill, SC
- Date: April, 2009
- Authors/Presenters:
Greene, L. H.
- Computational approaches to study protein structure and folding
- Sponsoring Organization: Department of Chemistry, Hampton University
- Location: Hampton, VA
- Date: October, 2008
- Authors/Presenters:
Greene, L. H.
- Conserved Protein Structure Networks
- Sponsoring Organization: Shippensburg University
- Location: Shippensburg, PA
- Date: October, 2008
- Authors/Presenters:
Greene, L. H.
- Protein structure networks and the fold continuum
- Sponsoring Organization: Randolph-Macon College
- Location: Ashland, VA
- Date: October, 2008
- Authors/Presenters:
Greene, L. H.
- Computational approaches to study protein structure and folding
- Sponsoring Organization: Eastern Virginia Medical School
- Location: Norfolk, VA
- Date: April, 2008
- Authors/Presenters:
Greene, L. H.
- Computational approaches to study protein structure and folding
- Sponsoring Organization: Washington and Lee University
- Location: Lexington, VA
- Date: March, 2008
- Authors/Presenters:
Greene, L. H.
- Computational approaches to study protein structure and folding
- Sponsoring Organization: Department of Chemistry and Biochemistry, George Mason University
- Location: Fairfax, VA
- Date: April, 2007
- Authors/Presenters:
Greene, L. H.
- Computational approaches to study protein structure and folding
- Sponsoring Organization: Department of Computer Science, Norfolk State University
- Location: Norfolk, VA
- Date: April, 2007
- Authors/Presenters:
Greene, L. H.
- 'Bioinformatics to Proteomics' Course
- Sponsoring Organization: Birbeck College, University of London
- Location: London, UK
- Date: September, 2006
- Authors/Presenters:
Greene, L. H.
- Conference Name: FEBS, IUBMB
- Sponsoring Organization: FEBS, IUBMB
- Location: Budapest, Hungary
- Date: July, 2005
- Authors/Presenters:
Greene, L. H.
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Artistic and Professional Performances and Exhibits
- Type: Other
- The Plight of the Dusky
- Type: Novel
- 2010: Most Inspiring Faculty Mentor, Department of Chemistry and Biochemistry (Top Graduating Biochemistry Senior)
- 2009: Most Inspiring Faculty Mentor, Department of Chemistry and Biochemistry (Top Graduating Biochemistry Senior)
- 1996: Army Commendation Medal (for service in Combat Support Hospital in the U.S. Army Reserves), U.S. Army
- 1994: Army Commendation Medal (for service in Combat Support Hospital in the U.S. Army Reserves), U.S. Army
- 1993: National Service Defense Medal, U.S. Army Health Sciences Academy
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Contracts, Grants and Sponsored Research