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- Wayne Hynes
- Professor
- Department of Biological Sciences
- 202f Mills Godwin Bldg
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Norfolk,
VA
23529
- 757-683-3613
- whynes@odu.edu
- Web Page
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Education
- Otago University (New Zealand),
1985
- Major: Microbiology
- Degree: Ph. D.
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Expertise
- Biology
- Infectious disease agents and mechanisms of disease (NOT treatment or diagnosis) / Microbiology / Bioterrorism agents / Innate
immunity
- Microbiology
- Tick-Borne diseases
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Book Chapters
- Hynes, W. L. How ticks control microbes: innate immune responses.Biology of Ticks. NY: Oxford University Press.
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Articles
- L, W. C., Hynes, W. L., White, B. T., Marshall, M. N., Gaff, H., and Gauthier, D. Single-tube real-time PCR assay for differentiation of Ixodes affinis and Ixodes scapularis..
- Dobbs, F., Goodrich, A. L., and Thomson, F. K. (2013). Pandemic serotypes of Vibrio cholerae isolated from ships’ ballast tanks and coastal waters: Assessment of antibiotic resistance
and virulence genes (tcpA and ctxA).. Microbial Ecology
- Fedrow, A., Wright, C., Gaff, H., Sonenshine, D., Hynes, W. L., and Richards, A. (2012). In vitro propagation of Candidatus Rickettsia andeanae isolated from Amblyomma maculatum. FEMS Immunology and Medical Microbiology, 64 (74-81),
- Nadolny, R. M., Wright, C. L., Hynes, W. L., Sonenshine, D., and Gaff, H. (2011). Ixodes affinis (Acari: Ixodidae) in southeastern Virginia and implications for the spread of Borrelia burgdorferi, the agent
of Lyme disease. Journal of Vector Ecology, 36 (2), (pp. 464 - 467).
- Wright, C., Nadolny, R., Jiang, J., Richards, A., Sonenshine, D., Gaff, H., and Hynes, W. L. (2011). Tidewater Spotted Fever: Detection of Rickettsia parkeri in Gulf Coast ticks, southeastern Virginia. Emerging Infectious Diseases, 17 (5), (pp. 896-898).
- Turner, L. A., McCombs, G., Hynes, W. L., and Tolle, S. L. (2009). A novel approach to controlling bacterial contamination on toothbrushes: chlohexidine coating. Int. J. Dent. Hyg., 7 (4), (pp. 241-245).
- Hynes, W. L., Johnson, C., and Stokes, M. (2009). A single nucleotid mutation results in loss of enzymatic activity in the hyaluronate lyase gene of Streptococcus pyogenes. Microbial Path., 47, (pp. 308-313).
- Morris, A. D., McCombs, G. B., Akan, T., Hynes, W. L., Laroussi, M., and Tolle, S. L. (2009). Cold Plasma Technology: Bactericidal effects of Geobacillus stearothermophilus and Bacillus cereus microorganisms. J. Dent. Hyg., 83, (pp. 55-61).
- Wyatt, K. B., Campos, P. F., Gilbert, M. T., Kolokotronis, S., Hynes, W. L., DeSalle, R., Ball, J., Daszak, P., MacPhee, D. E., and Greenwood, A. D. (2008). Historical mammal extinction on Christmas Island (Indian Ocean) correlates with introduced infectious disease. PLoS ONE, 3 (11),
- Sonenshine, D., and Hynes, W. L. (2008). Molecular characterization and related aspects of the innate immune response in ticks. Front. Biosci., 13, (pp. 7046-7063).
- Kocan, K. M., de la Fuenta, J., Manzano-Roman, R., Naranjo, V., Sonenshine, D., and Hynes, W. L. (2008). Silencing expresion of the defensin, varisin, in male Dermacentor variabilis by RNA intereference results in reduced Anaplasma
marginale infections. Exp. Appl. Acarol., 46, (pp. 17-28).
- Hynes, W. L., and Berling, K. Spy1600 of S. pyogenes does not appear to have hyaluronidase activity.
- Walton, S., and Hynes, W. L. The Effect of Environmental Conditions on Hyaluronate Lyase Gene Expression in the M-type 22.
- Laroussi, M., Hynes, W. L., Akan, T., Lu, X., and Tendero, C. (2008). The Plasma Pencil: A source of hypersonice cold plasma bullets forbiomedical applications. IEEE Transact Plasma Sci., 36, (pp. 1298-1299).
- Hynes, W. L., Stokes, M. M., Hensley, S. M., Todd, S., and Sonenshine, D. (2008). Using RNA interference to determine the role of varisin in the innate immune system of the hard tick Dermacentor variabilis
(Acari: Ixodidae). Exp. Appl. Acarol., 46, (pp. 7-15).
- Todd, S., Sonenshine, D., and Hynes, W. L. (2007). Tissue and life stage distribution of a defensin-like gene in the Lone Star tick Amblyomma americanum. Med. Vet. Entomol., 21, (pp. 141-147).
- Laroussi, M., Tendero, C., Lu, X., Alla, S., and Hynes, W. L. (2006). Inactivation of bacteria by the Plasma Pencil. Plasma Process. Polym., 3, (pp. 470-473).
- Marshall, H., Hargraves, P. E., Burkholder, J. M., Parrow, M. P., Elbrachter, M., Allen, E. H., Knowlton, V. M., Rublee, P. A., Hynes, W. L., Egerton, T. A., Remington, D. L., Wyatt, K. B., Lewitus, A. J., and Henrich, V. C. (2006). Taxonomy of Pfiesteria (Dinophyceae). Harmful Algae, 5, (pp. 481-496).
- Hynes, W. L., Ceraul, S. M., Todd, S., Seguin, K. C., and Sonenshine, D. (2005). A defensin-like gene expressed in the black-legged tick, Ixodes scapularis. Med. Vet. Entomol., 19, (pp. 339-344).
- Sonenshine, D., Hynes, W. L., Ceraul, S. M., Mitchell, R., and Benzine, T. (2005). Host blood proteins and peptides in the midgut of the tick Dermacentor variabilis (Say) contribute to bacterial control. Exp. Appl. Acarol., 36, (pp. 207-223).
- Ceraul, S. M., Sonenshine, D. E., Ratzlaff, R. E., and Hynes, W. L. (2003). An arthropod defensin expressed by the hemocytes of the American dog tick, Dermacentor variabilis (Acari: Ixodidae). Insect Biochemistry and Molecular Biology, 33, (pp. 1099-1103).
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Presentations
- Survey of Ticks in the Hampton Roads area: Rickettsia parkeri
- Conference Name: VMCA
- Sponsoring Organization: VMCA
- Location: Virginia Beach, VA
- Date: February, 2011
- Authors/Presenters:
Wright, C. Presenter & Author
Gaff, H. Author Only
Nadolny, R. Author Only
Sonenshine, D. Author Only
Hynes, W. L. Author Only
- Survey of Ticks in the Hampton Roads area: Tick populations
- Conference Name: VMCA
- Sponsoring Organization: VMCA
- Location: Virginia Beach, VA
- Date: February, 2011
- Authors/Presenters:
Nadolny, R. Presenter & Author
Gaff, H. Author Only
Wright, C. Author Only
Hynes, W. L. Author Only
Sonenshine, D. Author Only
- Introduction of active hyaluronate lyase into non-producing serotypes of S. pyogenes
- Conference Name: VA Branch of the American Society for Microbiology
- Sponsoring Organization: VA Branch of the American Society for Microbiology
- Location: Lynchburg, VA
- Date: November 5, 2010
- Authors/Presenters:
Sloan, M. Presenter Only
Hynes, W. L. Author Only
- Tidewater spotted fever: detection of R. parkeri in gulf coast ticks in southeastern Virginia
- Conference Name: VA Branch of the American Society for Microbiology
- Sponsoring Organization: VA Branch of the American Society for Microbiology
- Location: Lynchburg, VA
- Date: November 5, 2010
- Authors/Presenters:
Wright, C. Presenter Only
Nadolny, R. Author Only
Sonenshine, D. Author Only
Gaff, H. Author Only
Hynes, W. L. Author Only
- Effects of Low-Temperature Atmospheric Pressure Plasma on Streptococcus mutans
- Conference Name:
- Location: Washington, DC
- Date: June, 2009
- Authors/Presenters:
Lemaster, M. F.
McCombs, G.
Darby, M. M.
Hynes, W. L.
Laroussi, M.
- Effects of Low-Temperature Atmospheric Pressure Plasma on Streptococcus mutans
- Conference Name:
- Location: Bethesda, MD
- Date: June, 2009
- Authors/Presenters:
Lemaster, M. F.
McCombs, G.
Darby, M. M.
Hynes, W. L.
Laroussi, M.
- Effects of Low-temperature Atmospheric Pressure Plasma Pencil on Streptococcus mutans.
- Conference Name:
- Location: Bethesda, MD
- Date: June, 2009
- Authors/Presenters:
Lemaster, M. F.
Darby, M. M.
Hynes, W. L.
Laroussi, M.
- Hyaluronate lyase of Streptococcus pyogenes in negatively regulated by RegR.
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Boston, MA
- Date: 2008
- Authors/Presenters:
Stokes, M. Presenter & Author
Hynes, W. L. Presenter & Author
- Varisin is responsible for most of the defensin antimicrobial activity seen in the hemolymph of the hard tick Dermacentor
variabilis
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Boston, MA
- Date: 2008
- Authors/Presenters:
Hynes, W. L. Presenter & Author
Stokes, M. M. Presenter & Author
Hensley, S. M. Presenter & Author
Sonenshine, D. Presenter & Author
- Silencing defensin expression in the tick Dermacentor variabilis to examine its role in vector competency
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Richmond, VA
- Date: 2008
- Authors/Presenters:
Hensley, S. Presenter & Author
Stokes, M. Presenter & Author
Hynes, W. L. Presenter & Author
- Effects of Low-Temperature Atmospheric Pressure Plasma on Streptococcus mutans
- Conference Name:
- Location: Richmond, VA
- Date: February, 2008
- Authors/Presenters:
Lemaster, M. F.
McCombs, G.
Darby, M. M.
Hynes, W. L.
Laroussi, M.
- Inactivation of Varisin, a defensin of the tick Dermacentor variabilis, using RNA interference
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Toronto, Canada
- Date: 2007
- Authors/Presenters:
Hynes, W. L. Presenter & Author
Todd, S. Presenter & Author
Hensley, S. M. Presenter & Author
Sonenshine, D. Presenter & Author
- Understanding the structure-function relationship of the hyaluronate lyase of Streptococcus pyogenes
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Toronto, Canada
- Date: 2007
- Authors/Presenters:
Stokes, M. Presenter & Author
Monroe, C. Presenter & Author
Hynes, W. L. Presenter & Author
- Understanding the structure-function relationship of the hyaluronate lyase of Streptococcus pyogenes
- Conference Name:
- Location: Wintergreen, VA
- Date: 2007
- Authors/Presenters:
Stokes, M. Presenter & Author
Monroe, C. Presenter & Author
Hynes, W. L. Presenter & Author
- Bacterial effects of non-equilibrium cold plasma on Geobacillus stearothermophilus and Bacillus cereus
- Conference Name:
- Location: Prague, Czech Republic
- Date: July, 2007
- Authors/Presenters:
Hynes, W. L.
Laroussi, M.
- Bactericidal Effects of Cold Plasma Technology on Geobacillus Stearothermophilus and Bacillus Cereus Microorganisms
- Conference Name:
- Location: New Orleans, LA
- Date: June 22, 2007
- Authors/Presenters:
Laroussi, M.
Hynes, W. L.
- Bactericidal Effects of Cold Plasma Technology on Geobacillus Stearothermophilus and Bacillus Cereus Microorganisms
- Location: Old Dominion University Annual Research Exposition
- Date: April 5, 2007
- Authors/Presenters:
Laroussi, M.
Hynes, W. L.
- Loss of defensin protein and inhibitory activity in tick hemolymph by RNAi studies
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Lexington, VA
- Date: 2006
- Authors/Presenters:
Hensley, S. Presenter & Author
Todd, S. Presenter & Author
Sonenshine, D. Presenter & Author
Hynes, W. L. Presenter & Author
- Mutagenesis of One Nucleotide Affects Hyaluronate Lyase Activity in S. pyogenes
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Lexington, VA
- Date: 2006
- Authors/Presenters:
Monroe, C. Presenter & Author
Stokes, M. Presenter & Author
Hynes, W. L. Presenter & Author
- Trypanosomes and the extinction of Christmas Island rats (Rattus macleari)
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Lexington, VA
- Date: 2006
- Authors/Presenters:
Wyatt, K. Presenter & Author
Hynes, W. L. Presenter & Author
MacPhee, R. Presenter & Author
Greenwood, A. Presenter & Author
- Expression and Isolation of Varisin, the Defensin from the Hard Tick Dermacentor variabilis, from an insect cell line
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Lexington, VA
- Date: 2006
- Authors/Presenters:
Sharp, J. Presenter & Author
Hynes, W. L. Presenter & Author
- Effect of low temperature plasm on different bacteria genera
- Conference Name: American Society for Microbiology Annual Meeting
- Sponsoring Organization: American Society for Microbiology Annual Meeting
- Location: Orlando, FL
- Date: 2006
- Authors/Presenters:
Hynes, W. L. Presenter & Author
Tendero, C. Presenter & Author
Laroussi, M. Presenter & Author
- Efficacy of Chlorhexidine Coated Toothbrush Filaments in Controlling Bacterial Contamination
- Conference Name:
- Location: Orlando, Florida
- Date: June, 2006
- Authors/Presenters:
Tolle, S. L.
Hynes, W. L.
- Efficacy of Chlorhexidine Coated Toothbrush Filaments in Controlling Bacterial Contamination
- Conference Name:
- Location: Brisbane, Australia
- Date: June, 2006
- Authors/Presenters:
Tolle, S. L.
Hynes, W. L.
- The Efficacy of Chlorhexidine-Coated Toothbrush Filaments in Controlling Bacterial Contamination
- Location: Old Dominion University Annual Research Exposition
- Date: April, 2006
- Authors/Presenters:
Tolle, S. L.
Hynes, W. L.
- Assessing the potential for horizontal gene transfer of plasmid-borne antibiotic resistance in Vibrio cholerae isolated from
ships' ballast
- Conference Name: Estuarine Reseach Federation
- Sponsoring Organization: Estuarine Reseach Federation
- Location: Norfolk, VA
- Date: 2005
- Authors/Presenters:
Heinemann, S. A. Presenter & Author
Thomson, F. T. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. C. Presenter & Author
- Ships' ballast as a potential vector for the transfer of antibiotic resistance genes among estuarine environment
- Conference Name: Estuarine Reseach Federation
- Sponsoring Organization: Estuarine Reseach Federation
- Location: Norfolk, VA
- Date: 2005
- Authors/Presenters:
Thomson, F. Presenter & Author
Heinemann, S. A. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. C. Presenter & Author
- Defensin in ticks: molecular characterization, expression and role in innate immunity
- Conference Name: 5th International Conference on Ticks and Tick-borne Pathogens
- Sponsoring Organization: 5th International Conference on Ticks and Tick-borne Pathogens
- Location: Neuchatel, Switzerland
- Date: 2005
- Authors/Presenters:
Sonenshine, D. Presenter & Author
- The effects of insertional inactivation of response regulator genes on hyaluronate lyase and other virulence factors of Streptococcus
pyogenes
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Atlanta, GA
- Date: 2005
- Authors/Presenters:
Stokes, M. M. Presenter & Author
Hynes, W. L. Presenter & Author
- A Molecular Comparison of Pfiesteria And Pseudopfiesteria
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Norfolk, VA
- Date: 2005
- Authors/Presenters:
Wyatt, K. Presenter & Author
Hynes, W. L. Presenter & Author
- Assessing the Potential for Horizontal Gene Transfer of Plasmid-Borne Antibiotic Resistance in Vibrio cholerae Isolated from
Ships' Ballast
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Norfolk, VA
- Date: 2005
- Authors/Presenters:
Heinemann, S. A. Presenter & Author
Thomson, F. T. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. C. Presenter & Author
- Characterization of Antibiotic Resistance Genes in Vibrio cholerae Isolated From Ships' Ballast Tanks
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Norfolk, VA
- Date: 2005
- Authors/Presenters:
Thomson, F. K. Presenter & Author
Heinemann, S. A. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. C. Presenter & Author
- Defensin Tissue Distribution in Ixodes scapularis And Amblyomma americanum
- Conference Name: American Society for Microbiology
- Sponsoring Organization: American Society for Microbiology
- Location: Norfolk, VA
- Date: 2005
- Authors/Presenters:
Todd, S. Presenter & Author
Hynes, W. L. Presenter & Author
- Plasmid-borne antibiotic resistance in Vibrio cholerae isolates from ships' ballast
- Conference Name: Atlantic Estuarine Research Society
- Sponsoring Organization: Atlantic Estuarine Research Society
- Location: Solomons, MD
- Date: 2005
- Authors/Presenters:
Heinemann, S. A. Presenter & Author
Thomson, F. K. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. C. Presenter & Author
- Ships' ballast water as a potential source for the introduction of antibiotic resistance genes into estuarine environments
- Conference Name: Atlantic Estuarine Research Society
- Sponsoring Organization: Atlantic Estuarine Research Society
- Location: Solomons, MD
- Date: 2005
- Authors/Presenters:
Thomson, F. K. Presenter & Author
Heinemann, S. Presenter & Author
Goodrich, A. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. Presenter & Author
- Ships' ballast as a potential vector for the transfer of antibiotic-resistance genes of Vibrio cholerae
- Conference Name:
- Location: Gent, Belgium
- Date: 2005
- Authors/Presenters:
Thompson, F. Presenter & Author
Heinemann, S. A. Presenter & Author
Hynes, W. L. Presenter & Author
Dobbs, F. Presenter & Author
- A pathogenic herpes-like virus from the Caribbean spiny lobster
- Conference Name:
- Location: Washington, DC
- Date: 2004
- Authors/Presenters:
Ratzlaff, R. E.
Hartwig, C. L.
Cooper, R. A.
Hynes, W. L.
Shields, J. D.
- Detection of a pathogenic herpes-like virus from the Caribbean spiny lobster, Panulirus argus (HLV-PA) using a nested PCR
approach
- Sponsoring Organization: Virginia Branch of the American Society of Microbiology
- Location: Charlottesville, VA
- Date: 2003
- Authors/Presenters:
Hartwig, C. L.
Cooper, R. A.
Hynes, W. L.
Ratzlaff, R. E.
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Contracts, Grants and Sponsored Research