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- Patricia Hentosh
- Professor
- 2122 Health Sciences Bldg
-
Norfolk,
VA
23529
- 757-683-3611
- phentosh@odu.edu
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Education
- Ohio State University,
- Major: Zoology
- Degree: B.S.
- Harvard University, School of Public Health,
- Major: Cancer Biology, Radiation Biology
- Degree: S.M.
- Harvard University School of Public Health,
1984
- Major: Radiation biology, Cancer Biology
- Degree: Sc.D.
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Books
- Hentosh, P., and Tibudan, M. (1997). 2-Chloro-2'-deoxyadenosine, an antileukemic drug, has an early effect on cellular mitochondrial function. Molec Pharacol.
- Hentosh, P., Tibudan, M., and Grippo, P. (1995). A human factor that recognizes DNA substituted with 2-chloroadenine, an anitleukemic purine analog. Molec Carcinogenesis.
- Hentosh, P., and Tibudan, M. (1995). In vitro transcription of DNA containing 2-chloro-2'-deoxyadenosine monophosphate. Molec-Pharmacol.
- Hentosh, P., and Grippo, P. (1994). 2-chloro-2'-deoxyadenosine monophosphate residues in DNA enhance susceptibility to 3' to 5' exonucleases. Biochem J.
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Book Chapters
- Peffley, D. M., and Hentosh, P. (2012). Plant-derived isoprenoids mediate regulation of mTOR signaling in tumor cells.“Natural Compounds as Inducers of Cell Death” (pp. 373-400). Springer Publishing.
- Hentosh, P., Peffley, D. M., Sharma, C., and Buechler, R. D. (2007). Perillyl alcohol and genistein differentially regulate PKB/Akt and 4E-BPI phosphorylation as well as eIF4E/eIF4G interactions
in human tumor cells. (pp. 266-273). Arch Biochem Biophys.
- Hentosh, P., Hartman, W. R., and Walters, D. E. (2007). Presence of the anti-leukemic nucleotide analog, 2-chloro-2'- deoxyadenosine- 5'- monophosphate, in a promoter sequence alters
DNA binding of TATA bindingprotein (TBP).. (pp. 223-232). Arch Biochem Biophys.
- Hentosh, P., Foley, T., and Walters, D. E. (2004). 2-Chloro-2' -deoxyadenosine:Alteration of DNA: TATA element binding protein (TBP) interactions. (pp. 32-37). J. Molec Model.
- Hentosh, P., and Hartman, W. R. (2004). The anti-leukemia drug 2-chloro-2' -deoxyadenosine: An intrinsic trasncriptional antagonist. (pp. 227-234). Molec Pharmacol.
- Hentosh, P., Lawrenzi, J., and Bunnell, A. (2003). Nucleotide excision repair-deficient human cells in culture exhibit decreased survival after 2- chlorodeoxyadenosine treatment. (pp. 3141-3146). Anticancer Res.
- Hentosh, P., Yuh, S. H., Elson, C. E., and Peffley, D. M. (2001). Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A n(HMG-CoA) reductase in tumor cells. (pp. 154-166). Molec Carcinog.
- Hentosh, P., Elson, C. E., Peffly, D. M., and Mo, H. (1999). Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. (pp. 294-311). Proc Soc Exper Med.
- Hentosh, P., Yuh, S. H., and Tibudan, M. (1998). Analysis of 2-chloro-2'deoxyadenosine incorporation into cellular DNA by quantitative ploymerase chain reaction.. (pp. 1-8). Analytic Ciochem.
- Hentosh, P., McCastlain, J. C., Grippo, P., and Bugg, B. Y. (1992). Ploymerasechain reaction amplification of single-stranded DNA containing a base analog, 2-chloroadenine. (pp. 277-281). Analytical Biochem.
- Hentosh, P., McCastlain, J. C., and Blakley, R. L. (1991). Effects of 2-chloro-2'-deoxyadenine 5' triphosphate on DNA synthesis in vitro by purified bacterial and viral DNA polymerases. (pp. 547-554). Biochem.
- Hentosh, P., and McCastlain, J. C. (1991). Effects of 2-choloradenine substitution in DNA on restriction endonuclease cleavage reactions. (pp. 3143-3148). Nucleic Acids Res.
- Hentosh, P., Collins, A., Correll, L., Fornace, A. J., Giaccia, A., and Waldren, C. A. (1990). Genetic and biochemical characterization of the CHO-UV-1 mutant defective in post replication recovery of DNA. (pp. 2356-2362). Cancer Res.
- Hentosh, P., Koob, R., and Blakely, R. L. (1990). Incorporated of 2-halogeno-2'deoxyadenosine 5'-triphosphates into DNA during replication by human polymerases a and b. (pp. 4033-4040). J Boil Chem.
- Hentosh, P. (1988). The induction and repair of DNA damage in y-irradiated human lymphoblasts: irradiation in the presence and absence of misonidazole. (pp. 436-447). Radiant Res.
- Hentosh, P., Henner, W. D., and Reynolds, R. J. (1985). Sequence specificity of DNA cleavage by Micrococcus luteus gamma endonuclease. (pp. 119-129). Radiat Res.
- Hentosh, P. (1977). Survival differences exhibited by normal and transformed rat liver epithelial cell lines in the aggrgate form. (pp. 1864-1867). Cancer Res.
- Hentosh, P., Steuer, A., Rhim, J., and Ting, R. (1977). Survival of human cells in the aggregate for,: potential index of in vitro cell transformation. (pp. 917-921). J Natl Cancer Inst.
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Articles
- Sundin, T., Peffley, D. M., and Hentosh, P. (2013). Disruption of an hTERT-mTOR-RAPTOR protein complex by a phytochemical perillyl alcohol and rapamycin.. Molecular Cellular Biochemistry, 375, (pp. 97-104).
- Sundin, T., and Hentosh, P. (2012). InTERTesting association among telomerase, mTOR, and phytochemicals. Expert Reviews Molec Medicine, 14 (e8),
- Sundin, T., Peffley, D. M., Gauthier, D., and Hentosh, P. (2012). The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells.. Biochimie, 94, (pp. 2639-48).
- Hentosh, P., Benjamin, T., Hall, L., Leap, S., Loescher, J., Poyner, E., Sundin, T., Whittle, M., Wilkinson, S., and Peffley, D. M. (2011). Xeroderma Pigmentosum Variant: Complementary molecular approaches to detect a 13 bp deletion in the polymerase eta gene.. Exp Molec Pathology, 91, (pp. 528-33).
- Hentosh, P., and Peffley, D. M. (2010). The cladribine conundrum: deciphering the drug’s mechanism of action.. Expert Opinion Drug Metabolism Toxicology, 6, (pp. 75-81).
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Presentations
- Perillyl alcohol and rapamycin-mediated inhibition of migration and invasion.
- Conference Name:
- Location: Boston, MA
- Date: April, 2013
- Authors/Presenters:
Sundin, T.
Peffley, D. M.
Hentosh, P.
- The isoprenoid perillyl alcohol inhibits telomerase activity in prostate cancer cells
- Conference Name: Experimental Biology
- Sponsoring Organization: Experimental Biology
- Location: San Diego, CA
- Date: April, 2012
- Authors/Presenters:
Sundin, T.
Gauthier, D.
Peffley, D. M.
Hentosh, P.
- Identifying potential lung cancer protein bioinformatics and mass spectrometry
- Conference Name:
- Location: Norfolk, VA
- Date: April, 2008
- Authors/Presenters:
Hentosh, P.
Thomas, S.
Bonchev, D.
Hill, K.
Hatcher, P.
Thompson, S. K.
Kier, L.
Peffley, D. M.
- Identifying potential lung cancer protein biomarkers by bioinformatics and mass spectrometry
- Conference Name:
- Date: March, 2008
- Authors/Presenters:
Hentosh, P.
Thomas, S.
Bonchev, D.
Hill, K.
Hatcher, P.
Thompson, S. K.
Kier, L.
Peffley, D. M.
- Proteomic analysis of cellular responses to the anti-leukemic drug and nucleoside analog, 2-chloro-2'-deoxyadenosine (Cladribine).
- Conference Name:
- Location: Norfolk, VA
- Date: 2007
- Authors/Presenters:
Hentosh, P.
Sheets, D.
Peffley, D.
Sharma, C.
Shipulina, N.
Morgan, W.
Keightly, A.
- Regulation of 14-3-3 protein in PC3 human prostate tumor cells through the mTOR (mammalian Target of Rapamycin) signal transduction
pathway
- Conference Name:
- Location: Norfolk, VA
- Date: 2007
- Authors/Presenters:
Hentosh, P.
Peffley, D.
Sharma, C.
Morgan, W.
Shipulina, N.
Keightly, A.
- Complex analysis of chromatin-associated genes in lung adenocarcinoma
- Conference Name:
- Date: June, 2007
- Authors/Presenters:
Hentosh, P.
Thomas, S.
Bonchev, D.
Peffley, D.
- Regulation of inflammatory mediator screction by dietary isoprenoids in an in vitro model of atherosclerosis.
- Conference Name:
- Date: April, 2005
- Authors/Presenters:
Hentosh, P.
Buxton, B. A.
Tanner, S.
Peffley, D.
- Conference Name:
- Location: Crete, Greece
- Date: October, 2004
- Authors/Presenters:
Hentosh, P.
- Effects of a 2-cholordeoxyadenosine monophosphate-subsituted TATA element on in vivo gene expression
- Conference Name: American Association for Cancer Research
- Sponsoring Organization: American Association for Cancer Research
- Date: March, 2004
- Authors/Presenters:
Hentosh, P.
Lawrenzi, J.
Savage, J.
Bunnell, A.
- 2-Chlorodeoxyadenosine: Mechanism of disruption of DNA: TATA element binding protein (TBP) interactions.
- Conference Name: American Association for Cancer Research
- Sponsoring Organization: American Association for Cancer Research
- Date: July, 2003
- Authors/Presenters:
Hentosh, P.
Foley, T.
Walters, D. E.
- Differential inhibition of invasive properties in PC3 and DU145 cancer cells by genistein, perilly alcohol and gamma-tocotrienol.
- Conference Name: American Association for Cancer Research
- Sponsoring Organization: American Association for Cancer Research
- Date: July, 2003
- Authors/Presenters:
Hentosh, P.
Sharma, N.
Peffley, D.
- The effect of incorporating 2-chlorodeoxyadenosine (Cladribine) into the TATA element of DNA and the TATA element binding
protein (TBP) core domain complexed to the TATA element
- Conference Name:
- Date: October, 2001
- Authors/Presenters:
Hentosh, P.
Foley, T.
Walters, D. E.
- Isoprenoids initiate G1 arrest and apoptosis with specificity for tumor cells
- Conference Name:
- Date: 1999
- Authors/Presenters:
Hentosh, P.
Mo, H.
Peffley, D.
Elson, C. E.
- Sterol-independent regulation of tumor cell 3-hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) reductase
- Conference Name: American Association for cancer Research
- Sponsoring Organization: American Association for cancer Research
- Date: April, 1999
- Authors/Presenters:
Hentosh, P.
Yuh, S. H.
Elson, C. E.
Peffley, D.
- IC50 values for the suppression of B16 melanoma cell proliferation by monoterpenoid derivatives.
- Conference Name:
- Date: 1998
- Authors/Presenters:
Hentosh, P.
Mo, H.
Peffley, D. M.
Elson, C. E.
- Sterol-independent regulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in tumor cells: relationship to
promoter methylatuion
- Conference Name:
- Date: August, 1998
- Authors/Presenters:
Hentosh, P.
Yuh, S. H.
Elson, C. E.
Peffley, D. M.
- Functional consequences of the modulation of 3-hydroxy-3-methylglutaryl Coenzyme A reductase by isoprenoids
- Conference Name: American Association for Cancer Research
- Sponsoring Organization: American Association for Cancer Research
- Date: April, 1998
- Authors/Presenters:
Hentosh, P.
Elson, C. E.
Mo, H.
Peffley, D. M.
- Mitochondrial effects of 2-chlorodeoxyadenosine
- Conference Name: American Association for cancer Research
- Sponsoring Organization: American Association for cancer Research
- Date: April, 1997
- Authors/Presenters:
Hentosh, P.
Tibudan, M.
Callaci, j.
- End products of plant mevalonate pathways induce apoptosis in tumor cells
- Conference Name:
- Date: April, 1997
- Authors/Presenters:
Hentosh, P.
Mo, H.
Peffley, D. M.
Elson, C. E.
- Alpha Lambda Delta National Honorary Scholastic Society
- 2008: Excellence Award in Molecular Medicine
- 2004: Nominated for the 2004 Irvin Korr Basic Science Research Aard, American Osteopathic Association
- Ohio State University Presidential Scholar
- 2012: Outstanding Faculty Member, Old Dominion University Graduate Program
- Phi Beta Kappa
- 2001: Recipient of the $10,000 INcentive Award (top application) from the Say Health Research Program for pre-proposal research
study entitled "Cancer preventive effects of genistein on prostate cancer", Say Health Research Program
- 2002: Recipient of the Univeristy of Health Sciences Faculty Publication Award, Univerity of Health Sciences
- 2002: Recipient of the University of Health Sciences Research Support Award, University of Health Sciences
- Predoctoral Fellowship, National Cancer Institute
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Contracts, Grants and Sponsored Research