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- Michael Stacey
- Research Associate Professor
- Frank Reidy Center for Bioelectrics
- 300 4211 Monarch Way
- BS in Zoology and PhD in cancer studies at the University of Hull and University of Birmingham, England. Fellowships at the
University of Birmingham, and Oxford, England, before coming to EVMS in 1997.
Moved to the Center for Bioelectrics ODU in 2007.
- University Of Birmingham,
- Major: Cancer Biology
- Degree: Ph. D.
- Research interests.
My research interests are in the area of Biomedicine, understanding the causes of disease and their underlying biology.
1). Pectus excavatum is a common inherited chest wall deformity where the sternum is depressed towards the spinal column,
compressing the chest and affecting heart and lung function. The underlying cause is thought to be due to mechanical weakness
in the chest cartilage, likely due to abnormal protein deposition or interaction. The mechanical properties of cartilage closely
correlate with the electrical properties, and therefore we expect both properties to be compromised in affected costal cartilages.
The internal electrical charge of cartilage is responsible for influx of solutes, which gives cartilage both strength and
pliability. We are investigating changes in electrical and mechanical properties of proteins in individuals with pectus excavatum
as potential underlying causes. We consider it artificial to separate mechanical responses from electrical responses in this
biological tissue, as one is very dependent upon the other. This disorder is a model for uniting biomechanics and bioelectrics
with the advantages of patient benefit.
2). Carbon nanotubes are finding increased use in biological and medical applications. They possess unique physical, chemical
and electrical properties that could be utilized in the treatment of disease. Electrically, carbon nanotubes are a basic building
block for nanometer scaled electronic structures and have the world's highest conductivity per unit mass. Although there are
many conflicting reports regarding the toxicity of carbon nanotubes, the design of carbon nanotubes for specific biological
applications hold great promise. The sensitivity of carbon nanotubes integrated with biological cultures and exposed to external
stimuli has shown destruction of cells, thus indicating their use as synergistic agents of cell death. We propose to utilize
the electrical properties of multi-walled carbon nanotubes (MWCNTs) to synergistically enhance pulse electric field effect
induced cell death.
- Stacey, M. W., and Osgood, C. J. (2011). Nanosecond pulse electrical fields used in conjunction with mutli-wall carbon nanotubes as a potential tumor treatment.. Biomed Mater, 6, (pp. 011002).
- Osgood, C. J., Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Nuccitelli, R., Pakhomov, A., Stacey, M. W., Swanson, R. J., White, J., Xiao, S., and Zhang, J. (2007). Bioelectric effects of intense nanosecond pulses. IEEE Transact Dielectrics Electrical Insul, 14, (pp. 1088-1109).
- Sun, Y., Xiao, S., White, J. A., Kolb, J. F., Stacey, M. W., and Schoenbach, K. H. (2007). Compact, Nanosecond, High Repetition-Rate, Pulse Generator for Bioelectric Studies. IEEE Trans. Dielectrics and Electrical Insulation, 14 (4),
- Conference Name:
- Location: Charleston SC
- Date: October 25, 2010
Contracts, Grants and Sponsored Research