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- Juergen Kolb
- Assistant Professor
- Frank Reidy Center for Bioelectrics
- 4211 Monarch Way Suite 300
-
Norfolk,
VA
23529
- 757-683-2414
- jkolb@odu.edu
- Dr. Kolb graduated with the first state exam in mathematics and physics from the University of Erlangen-Nuremberg in 1995.
He received a Dr. rer. nat. degree in physics at the same University in 1999. As a postdoctoral research associate at the
Technische Hochschule Darmstadt he continued to work on the interaction of heavy ion beams with plasmas until he switched
into the higher education school service to pursue a teaching degree for mathematics and physics from 2000 till 2002. He maintains
a strong interest in the didactic of these subjects. After his graduation with the second state exam, he accepted a position
as postdoctoral research assistant at the Physical Electronics Research Institute at Old Dominion University, then transitioned
to the Frank Reidy Research Center for Bioelectrics. In 2004, he was hired as Research Assistant Professor, and in 2006 accepted
an Assistant Professorship in the Department of Electrical and Computer Engineering at Old Dominion University. His research
at the Center for Bioelectrics relates to the effects of pulsed electric fields in biological, medical and environmental applications.
The immediate physical response to an electric stimulus, in particular, the charging behaviour of cells and tissues, is currently
the main focus of his work. Other research activities in which he is engaged include the generation, diagnostic and applications
of gas discharge plasmas and the physics and technologies of pulsed power systems.
-
Education
- ,
2002
- Major: Mathematics and Physics
- Degree: 2nd State Examination in Mathematics and Physics
- Universityersitat Erlangen - Nurnberg,
1999
- Major: Physics
- Degree: Ph. D.
- ,
1995
- Major: Mathematics and Physics
- Degree: 1st State Examination in Mathematics and Physics
-
Research Interests
- -Energy storage and electrical breakdown in liquid dielectrics
-Response of mammalian cells to pulsed electric fields
-Pulsed power applications for medical and environmental applications
-High pressure glow discharges and their applications in medicine and surface processing
-Micro discharges and their applications as ultraviolet light sources and lasers
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Articles
- Nuccitelli, R., Chen, X., Pakhomov, A., Baldwin, W., Sheikh, S., Pomicter, J., Ren, W., Osgood, C., Kolb, J. F., Beebe, S., and Schoenbach, K. H. A New Pulsed Electric Field Therapy for Melanoma Disrupts the Tumor’s Blood Supply and Causes Complete Remission without Recurrence. Intern. J. Cancer (125), (pp. 438-445).
- Chen, X., Kolb, J. F., Swanson, R. J., Schoenbach, K. H., and Beebe, S. J. Apoptosis Initiation and Angiogenesis Inhibition: Melanoma Targets for Nanosecond Pulsed Electric Fields. Pigment Cell Melanoma Research, 23, (pp. 554).
- Chen, X., Swanson, R. J., Kolb, J. F., and Schoenbach, K. H. Histopathology of Normal Skin and Melanomas after Nanosecond Pulsed Electric Field (nsPEF) Treatment. Melanoma Research, 19, (pp. 361-371).
- Scarlett, S., White, J., Blackmore, P., Schoenbach, K. H., and Kolb, J. F. Regulation of Intracellular Calcium Concentration by Nanosecond Pulsed Electric Fields. Biochimica et Biophysica Acta – Biomembranes
- Nuccitelli, R., Chen, X., Pakhomov, A., Baldwin, W., Sheikh, S., Pomicter, J., Ren, W., Osgood, C., Swanson, R., Kolb, J. F., Beebe, S., and Schoenbach, K. A New Pulsed Electrid Field Therapy for Melanoma Disrupts the Tumor’s Blood Supply and Causes Complete Remission without Recurrence. Int. J. Cancer
- Joshi, R., Kolb, J. F., Xiao, S., and Schoenbach, K. H. (2009). Aspects of Plasma in Water: Streamer Physics and Applications. Plasma Processes and Polymers, 6, (pp. 763-777).
- Xiao, S., Joshi, R., Kolb, J. F., and Schoenbach, K. H. (2009). Nanosecond, Electrical Triggering of Water Switches. IEEE Trans. Plasma Science, 26, (pp. 1066-1075).
- Scarlett, S., White, J., Blackmore, P., Schoenbach, K., and Kolb, J. F. Regulation of Intracellular Calcium Concentrations by Nanosecond Pulsed Electric Fields. Biochimica et Biophysica Acta - Biomembranes
- Xiao, S., Joshi, R., Kolb, J. F., and Schoenbach, K. H. (2009). Nanosecond, Electrical Triggering of Water Switches. IEEE Trans. Dielectrics and Electrical Insulation, 16 (4), (pp. 1066-1075).
- Kolb, J. F., Mohamed, A., Price, R., Swanson, J., Bowman, A., Chiavarini, R., Stacey, M., and Schoenbach, K. H. (2008). Cold atmospheric pressure air plasma jet for medical applications. Appl. Phys. Lett., 92 (241501),
- Schoenbach, K. H., Kolb, J. F., Xiao, S., Katsuki, S., Minamitani, Y., and Joshi, R. (2008). Electrical Breakdown of Water in Microgaps. Plasma Sources Sci. Technol., 17 (024010),
- Angelis, A., Kolb, J. F., Zeni, L., and Schoenbach, K. H. (2008). Kilovolt, Nanosecond Pulse Generator with Variable Pulse Duration. Rev. Sci. Instrum., 79 (044301),
- Kolb, J. F., Joshi, R., Xiao, S., and Schoenbach, K. H. (2008). Streamers in water and other dielectric liquids. J. Phys. D: Appl. Phys., 41 (234007),
- Kolb, J. F., Joshi, R., Xiao, S., and Schoenbach, K. H. (2008). Streamers in Water and Other Dielectric Liquids. J. Phys. D: Appl. Phys., 41 (234007),
- Schoenbach, K. H., Xiao, S., Joshi, R., Camp, J., Heeren, T., Kolb, J. F., and Beebe, S. (2008). The Effect of Intense Subnanosecond Electrical Pulses on Biological Cells. IEEE Trans. Plasma Sci., 36 (414),
- Schoenbach, K. H., Xiao, S., Joshi, R., Camp, J. T., Heeren, T., Kolb, J. F., and Beebe, S. J. (2008). The Effect of Intense Subnanosecond Electrical Pulses on Biological Cells. IEEE Trans. Plasma Science, 36 (2), (pp. 414).
- Heeren, T., Camp, J., Katsuki, S., Akiyama, H., Kolb, J. F., and Schoenbach, K. H. (2007). 250kV Sub-Nanosecond Pulse Generator with Adjustable Pulse-width. IEEE Trans. Diel. Electr. Insul., 14, (pp. 884).
- Osgood, C. J., Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Nuccitelli, R., Pakhomov, A., Stacey, M. W., Swanson, R. J., White, J., Xiao, S., and Zhang, J. (2007). Bioelectric effects of intense nanosecond pulses. IEEE Transact Dielectrics Electrical Insul, 14, (pp. 1088-1109).
- Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Osgood, C., Nuccitelli, R., Pakhomov, A., Swanson, J., Stacey, M., White, J., Xiao, S., Zheng, J., Beebe, S., Blackmore, P., and Buescher, E. (2007). Bioelectric Effects of Nanosecond Pulses. IEEE Trans. Diel. Electr. Insul., 14 (1088),
- Schoenbach, K. H., Hargrave, B., Joshi, R., Kolb, J. F., Osgood, C. J., Nuccitelli, R., Pakhomov, A., Swanson, R. J., Stacey, M., White, J. A., Xiao, S., Zhang, J., Beebe, S. J., Blackmore, P. F., and Buescher, E. S. (2007). Bioelectric Effects of Nanosecond Pulses. IEEE Trans. Diel. Electr. Insul., 14 (5), (pp. 1088-1109).
- Sun, Y., Xiao, S., White, J., Kolb, J. F., Stacey, M., and Schoenbach, K. H. (2007). Compact, Nanosecond, High Repetition-Rate, Pulse Generator for Bioelectric Studies. IEEE Trans. Diel. Electr. Insul., 14, (pp. 863).
- Sun, Y., Xiao, S., White, J. A., Kolb, J. F., Stacey, M. W., and Schoenbach, K. H. (2007). Compact, Nanosecond, High Repetition-Rate, Pulse Generator for Bioelectric Studies. IEEE Trans. Dielectrics and Electrical Insulation, 14 (4),
- Pakhomov, A., Kolb, J. F., White, J. A., Joshi, R., Xiao, S., and Schoenbach, K. H. (2007). Long-Lasting Plasma Membrane Permeabilization in Mammalian Cells by Nanosecond Pulsed Electric Field (nsPEF). Bioelectromagnetics, 28, (pp. 655).
- Pakhomov, A., Kolb, J. F., White, J., Joshi, R., Xiao, S., and Schoenbach, K. H. (2007). Long-lasting plasma membrane permeabilization in mammalian cells by nanosecond pulsed electric fields (nsPEF). J. Bioelectromagnetics, 28 (655),
- Pakhomov, A., Shevin, R., White, J., Kolb, J. F., Pakhomova, O., Joshi, R., and Schoenbach, K. H. (2007). Membrane permeabilization and cell damage by ultrashort electric field shocks. Archives of Biochemistry and Biophysics, 465 (109),
- Chen, N., Garner, A., Chen, G., Jing, Y., Deng, Y., Swanson, R., Kolb, J. F., Beebe, S., Joshi, R., and Schoenbach, K. H. (2007). Nanosecond electric pulses penetrate the nucleus and enhance speckle formation. Biochemical and Biophysical Research Communications, 364 (220),
- Joshi, R., Nguyen, A., Sridhara, V., Hu, Q., Nuccitelli, R., Beebe, S., Kolb, J. F., and Schoenbach, K. H. (2007). Simulations of intracellular calcium release dynamics in response to a high-intensity, ultrashort electric pulse. Phys. Rev. E, 75 (041920),
- Garner, A., Chen, G., Chen, N., Sridhara, V., Kolb, J. F., Swanson, R., Beebe, S., Joshi, R., and Schoenbach, K. H. (2007). Ultrashort electric pulse induced changes in cellular dielectric properties. Biochemical and Biophysical Research, Communications (BBRC), 362 (139),
- Xiao, S., Kolb, J. F., Malik, M., Lu, X., Laroussi, M., Joshi, R., and Schoenbach, K. H. (2006). Electrical Breakdown and Dielectric Recovery of Polar Liquids. IEEE Trans. Plasma Science, 34, (pp. 1653-1661).
- Xiao, S., Kolb, J. F., Malik, M., Lu, X., Laroussi, M., Joshi, R., Schamiloglu, E., and Schoenbach, K. H. (2006). Electrical Breakdown and Dielectric Recovery of Propylene Car. IEEE Trans. Plasma Sci., 34, (pp. 1653).
- Hu, Q., Sridhara, V., Joshi, R., Kolb, J. F., and Schoenbach, K. H. (2006). Molecular Dynamics Analysis of High Electric Pulse Effects on Bilayer Membranes Containing DPPC and DPPS. IEEE Trans. Plasma Sci., 34, (pp. 1405).
- Kolb, J. F., Kono, S., and Schoenbach, K. H. (2006). Nanoscecond Pulsed Electric Field Generators for the Study of Subcellular Effects. J. Bioelectromagnetics, 27, (pp. 172).
- Nuccitelli, R., Pliquett, U., Chen, X., Ford, W., Swanson, R., Beebe, S., Kolb, J. F., and Schoenbach, K. H. (2006). Nanosecond pulsed electric fields cause melanomas to self-destruct. Biochemical and Biophysical Research, Communications (BBRC), 343, (pp. 351).
- Nuccitelli, R., Pliquett, U., Chen, X., Ford, W., Swanson, R., Beebe, S., Kolb, J. F., and Schoenbach, K. H. (2006). Nanosecond Pulsed electric fields cause melanomas to self-destruct. Biochemical and Biophysical Research Communications (BBRC), 343, (pp. 351).
- Walker, K., Pakhomova, O., Kolb, J. F., Schoenbach, K. H., Stuck, B., Murphy, M., and Pakhomov, A. (2006). Oxygen enhances lethal effect of high-intensity, ultrashort electrical pulses. Bioelectromagnetics, 27, (pp. 221).
- Walker, K., Pakhomova, O., Kolb, J. F., Schoenbach, K. H., Stuck, B., Murphy, M., and Pakhomov, A. (2006). Oxygen enhances lethal effect of high-intensity, ultrashort electrical pulses. Bioelectromagnetics J., 27, (pp. 221-225).
- Frey, W., White, J., Price, R., Blackmore, P., Joshi, R., Nuccitelli, R., Beebe, S., Schoenbach, K. H., and Kolb, J. F. (2006). Plasma Membrane Voltage Changes During Nanosecond Pulsed Electric Field Exposure. Biophys. J., 80, (pp. 3608).
- Frey, W., White, J., Price, R., Blackmore, P., Joshi, R., Nuccitelli, R., Beebe, S., Schoenbach, K. H., and Kolb, J. F. (2006). Plasma Membrane Voltage Changes During Nanosecond Pulsed Electric Field Exposure. Biophys. J., 90, (pp. 3608-3615).
- Qian, J., Joshi, R., Kolb, J. F., Schoenbach, K. H., Dickens, J., Neuber, A., Butcher, M., Cevallos, M., Krompholz, H., Schamiloglu, E., and Gaudet, J. (2005). Microbubble-based model analysis of liquid breakdown initiation by a submicrosecond pulse. J. Appl. Phys., 97 (113304),
- Tekle, E., Oubrahim, H., Dzekunov, S., Kolb, J. F., Schoenbach, K. H., and Chock, B. (2005). New approaches with nano-second electric pulses: Selective electroporation. Biophys. J., 89, (pp. 274).
- Tekle, E., Oubrahim, H., Dzekunov, S., Kolb, J. F., Schoenbach, K. H., and Chock, B. (2005). Selective field effects on intracellular vacuoles and vesicle membranes with nano-second electric pulses. Biophysical Journal, 89, (pp. 274-284).
- Malik, M., Minamitani, Y., Xiao, S., Kolb, J. F., and Schoenbach, K. H. (2005). Streamers in Water Filled Wire-Cylinder and Packed-Bed Reactors. IEEE Trans. Plasma Sci., 32, (pp. 490).
- Malik, M. A., Minamitani, Y., Xiao, S., Kolb, J. F., and Schoenbach, K. H. (2005). Streamers in Water Filled Wire-Cylinder and Packed-Bed Reactors. IEEE Trans. Plasma Science, 33, (pp. 490-491).
- Garner, A., Chen, N., Yang, J., Kolb, J. F., Swanson, R., Beebe, S., Joshi, R., and Schoenbach, K. H. (2004). A Time Domain Dielectric Spectroscopy Study of the Effects of Microsecond and Ultrashort Pulses on HL-60 Cell Suspensions. IEEE Trans. Plasma Sci., 32, (pp. 2073).
- Joshi, R., Qian, J., Zhao, G., Kolb, J. F., Schoenbach, K. H., Schamiloglu, E., and Gaudet, J. (2004). Are Microbubbles Necessary for the Breakdown of Liquid Water Subjected to a Sub-microsecond Pulse ?. J. Appl. Phys., 96, (pp. 5129).
- Joshi, R., Qian, J., Zhao, G., Kolb, J. F., and Schoenbach, K. H. (2004). Are microbubbles necessary for the breakdown of liquid water subjected to a submicrosecond pulse?. J. Appl. Phys., 96, (pp. 5129).
- Pakhomov, A., Phinney, A., Ashmore, J., Walker, K., Kolb, J. F., Kono, S., Schoenbach, K. H., and Murphy, M. (2004). Characterisation of the Cytoxic Effect of High-Intensity, 10-ns Electrical Pulses. IEEE Trans. Plasma Sci., 32, (pp. 1579).
- Schoenbach, K. H., Joshi, R., Kolb, J. F., Chen, N., Stacey, M., Blackmore, P., Buescher, E., and Beebe, S. (2004). Electrical Pulses Open a New Gateway into Biological Cells. Proc. IEEE, 92, (pp. 1122).
- Xiao, S., Kolb, J. F., Kono, S., Katsuki, S., Joshi, R., Laroussi, M., and Schoenbach, K. H. (2004). High Power Water Switches: Postbreakdown Phenomena and Dielectric Recovery. IEEE Trans. Diel. Elec. Insul., 11, (pp. 604).
- Xiao, S., Kolb, J. F., Kono, S., Katsuki, S., Joshi, R., Laroussi, M., and Schoenbach, K. H. (2004). High Power Water Switches: Postbreakdown Phenomena and Dielectric Recovery. IEEE Trans. on Dielectrics and Electrical Insulation, 11, (pp. 604-612).
- Chen, N., Schoenbach, K. H., Kolb, J. F., Garner, A., Yang, J., Swanson, R., and Beebe, S. (2004). Intracellular Effects of Nanosecond Electric Fields on Ce. Biochemical and Biophysical Research Communications (BBRC), 317, (pp. 421).
- Chen, N., Schoenbach, K. H., Kolb, J. F., Swanson, R., Garner, A., Yang, J., Joshi, R., and Beebe, S. (2004). Leukemic Cell Intracellular Responses to Nanosecond Electric Fields. Biochem. Biophys. Res. Comm. (BBRC), 317, (pp. 421).
- Gaudet, J., Barker, R., Buchenauer, C., Christodoulou, C., Dickens, J., Gundensen, M., Krompholz, H., Joshi, R., Kolb, J. F., Kuthi, A., Laroussi, M., Neuber, A., Nunnally, W., Schamiloglu, E., Schoenbach, K. H., Tyo, J., and Vidmar, R. (2004). Research Issues in Developing Compact Pulsed Power for High Peak Power Applications on Mobile Platforms. Proc. IEEE, 92, (pp. 1144-1165).
- Gaudet, J., Barker, R., Gundersen, M., Kuthi, A., Neuber, A., Dickens, J., Nunnally, W., Schamiloglu, E., Christodoulou, C., Tyo, S., Schoenbach, K. H., Joshi, R., Laroussi, M., Kolb, J. F., and Vidmar, R. (2004). Research Issuses in Developing Compact Pulsed Power for High Peak Power Applications on Mobile Platforms. Proc. IEEE, 92, (pp. 1144).
- Garner, A., Chen, N., Yang, J., Kolb, J. F., Swanson, R., Beebe, S., Joshi, R., and Schoenbach, K. H. (2004). Time Domain Dielectric Spectroscopy Measurements of HL-60 Cells Suspensions after Microsecond and Nanosecond Electrical Pulses. IEEE Trans. Plasma Science, 32, (pp. 2073-2084).
- Schoenbach, K. H., Joshi, R., Kolb, J. F., Chen, N., Stacey, m., Blackmore, P., Buescher, E., and Beebe, S. (2004). Ultrashort Electrical Pulses Open a New Gateway into Biological Cells. Proc. IEEE, 92, (pp. 1122-1137).
- Engelbrecht, M., Engelhardt, M., Flierl, H., Jacoby, j., Kolb, J. F., Kowalewicz, R., Meineke, A., Phillips, J., and Hoffmann, D. (1998). Numerical description and development of plasma stripper targets for heavy-ion beams. Nucl. Instr. Meth., A415, (pp. 621).
- Jacoby, J., Engelbrecht, M., Engelhardt, M., Flierl, H., Hoffmann, D., Kolb, J. F., Kowalewicz, R., Meineke, A., and Philipps, J. (1998). Swift ion plasma interaction experiments at Erlangen. Nucl. Instr. Meth., A415, (pp. 552).
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Presentations
- Treatment of skin infections with DC-operated afterglow air plasma jet
- Conference Name:
- Location: Norfolk, Virginia
- Date: June, 2010
- Authors/Presenters:
Kolb, J. F.
Heller, L. C.
Bowman, A. M.
Swanson, R. J.
Schoenbach, K. H.
- Exposure conditions for the treatment of solid tumors with nanosecond pulsed electric fields
- Conference Name:
- Location: Columbia, Missouri
- Date: June, 2009
- Authors/Presenters:
Kolb, J. F.
Chen, X.
Zhuang, J.
Ren, W.
Swanson, R. J.
Beebe, S. J.
Schoenbach, K. H.
- A Wide-Band Focusing System for Bioelectric Applications
- Conference Name: IEEE
- Sponsoring Organization: IEEE
- Location: Albuquerque, NM
- Date: 2007
- Authors/Presenters:
Xiao, S.
Migliaccio, M.
Camp, J. T.
Kolb, J. F.
Schoenbach, K. H.
Baum, C. E.
- From Submicrosecond to Subnanosecond Pulses-Entering a New Domain of Electric Field-Cell Interactions
- Conference Name:
- Location: Ottawa, Canada
- Date: July, 2007
- Authors/Presenters:
Schoenbach, K. H.
Xiao, S.
Camp, T.
Kolb, J. F.
Joshi, R.
Beebe, S. J.
- The Design of a Wide-band Antenna for Biomedical Applications
- Conference Name:
- Location: Ottawa, Canada
- Date: July, 2007
- Authors/Presenters:
Xiao, S.
Kolb, J. F.
Schoenbach, K. H.
Baum, C. E.
- A Nanosecond, High Repetition-Rate, All Water
- Conference Name: IEEE
- Sponsoring Organization: IEEE
- Location: Washington DC
- Date: May, 2006
- Authors/Presenters:
Sun, Y.
Xiao, S.
Kolb, J. F.
Schoenbach, K. H.
- Biological Effects of Intense Subnanosecond Electrical Pulses
- Conference Name: IEEE
- Sponsoring Organization: IEEE
- Location: Washington DC
- Date: May, 2006
- Authors/Presenters:
Schoenbach, K. H.
Katsuki, S.
Akiyama, H.
Heeren, T.
Kolb, J. F.
Xiao, S.
Camp, T.
Joshi, R.
Osgood, C. J.
Nuccitelli, R.
Beebe, S. J.
- Electrically Triggered Water Switches
- Conference Name: IEEE
- Sponsoring Organization: IEEE
- Location: Washington DC
- Date: May, 2006
- Authors/Presenters:
Xiao, S.
Sun, Y.
Kolb, J. F.
Pliquett, U.
Heeren, T.
Akiyama, H.
Schoenbach, K. H.
- Pulsed Power Generators and Delivery Devices for Bioelectrical Applications
- Conference Name:
- Location: Washington DC
- Date: May, 2006
- Authors/Presenters:
Heeren, T.
Kolb, J. F.
Xiao, S.
Schoenbach, K. H.
Akiyama, H.
- 2008: Nomination for the College of Engineering and Technology Excellence in Teaching Award, ODU BCET
- 2007: Recipient Department of Electrical and Computer Engineering Outstanding Teaching Award, ODU ECE Dept
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Contracts, Grants and Sponsored Research
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Intellectual Property
- Delivery Device, System, and Method for Delivering Nanosecond Pulsed Electric Fields
- Patent/Copyright: Patent
- Cold Air Atmospheric Pressure Micro Plasma Jet – Application, Method and Device
- Patent/Copyright: Patent
- Application of a Cold Air Atmospheric Pressure Micro Plasma Jet on Living Tissue such as Skin
- Patent/Copyright: Patent
- Modulation of Neuromuscular Functions with Ultrashort Pulses
- Patent/Copyright: Patent
- Method and Device for Creating a Microplasma Jet
- Patent/Copyright: Patent