Dennis Peffley

2149 HEALTH SCIENCES BLDG
NORFOLK, 23529

J.D. in Law, University of Missouri- Kansas City School of Law, (2005)

Ph.D. in Genetics, Pennsylvania State University, (1977)

M.S. in Genetics, Pennsylvania State University, (1974)

B.S. in Biology, Juniata College, (1972)

Contracts, Grants and Sponsored Research

Peffley, D. M. "A New Combination Therpay for Cancer treatment- Subnanosecond Electrical Pulse Treatment of Electro-Sensitized Tumors" $35,000. -
Peffley, D. M. "Minority Graduate Research Assistant Supplement" $49,000. -
Peffley, D. M. "Modeling and Testing Complex Interactions of Chromatin-associated Proteins in Cancer Cells" $78,000. -
Peffley, D. M. "Regulation of the Translation Interactome by Metabolically Active Lipids" $1,594,979. -
Peffley, D. M. "Microsoft A. Richard Newton Breakthrough Resaerch Award " $99,636. -
Peffley, D. M. "Modulation of Mevalonate Synthesis by Dietary Isoprenoids" $621,566. April 01, 1999 - March 30, 2006
Peffley, D. M. "Proteomic Analysis of Isoprenoid and isoflavone-mediated Regulation of Cap-dependent and Cap-independent Protein Translation in Human Prostate Tumor Cells" $25,000. December 01, 2003 - November 2004
Peffley, D. M. "Cancer Prevention by Isoprenoid Constituents of Plants" $250,000. September 01, 1996 - August 31, 2000
Peffley, D. M. "Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase by Mevalonate and Oxysterols" $120,000. July 01, 1996 - June 30, 2000
Peffley, D. M. "The Translational Control of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Mammalian Cells" $105,000. July 01, 1990 - June 30, 2000
Peffley, D. M. "Dietary Isoprenoid Regulation of Growth Related Genes" $50,000. December 01, 1996 - November 30, 1999
Peffley, D. M. "Regualtion of HMG CoA Reductase in Mammalian Cells" $441,417. January 01, 1990 - December 31, 1996
Peffley, D. M. "Regulation of HMG-CoA Reductase by Oxysterols and Mevalonate " $105,000. July 01, 1990 - June 30, 1993
Peffley, D. M. "Regulation of HMG-CoA Reductase Gene Expression" $25,000. April 01, 1989 - June 30, 1990
Peffley, D. M. "Regulation of HMG-CoA Reductase Gene Expression" $25,000. April 01, 1989 - June 30, 1990
Peffley, D. M. "The Translational Control of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Mammalian Cells" $55,000. July 01, 1988 - June 30, 1990
Peffley, D. M. "The Translational Control of HMG-CoA Reductase in mammalian Cells" $25,000. April 01, 1988 - March 31, 1989

Articles

Peffley, D. M., Sharma, C., Hentosh, P. and Buechler, R. D. (2007). Perrilly alcohol and genistein differentially regulate PKB/Akt and 4E-BPI phosphorylation as well as eIF/eIF4G interactions in human tumor cells. Arch. Biochem. Biophys 465 , pp. 266-273.
Peffley, D. M. and Buechler, R. (2004). Proto oncogene/eukaryotic translation initiation factor (eIF) 4E attenuates mevalonate-mediated regulation of 3-hydroxy-3-methylglutarly coenzyme A (HMG-CoA) reductase synthesis. Molec. Carcinog. 41 , pp. 39-53.
Peffley, D. M. and Gayen, A. K. (2003). Plant-derived monoteropenes suppress hamster kidney 3-hydroxy-3-methylglutarly coenzyme A reductase synthesis at the post-transcriptional level. J. Nutr 133 , pp. 38-44.
Peffley, D. M., Hentosh, P., Yuh, S. H. and Elson, C. E. (2001). Sterol-independent regulation of 3-hydroxy-3-methylglutarly coenzyme A reductase synthesis at the post-transcriptional level. J. Nutr. 32 , pp. 154-166.
Peffley, D. M., Elson, C. E., Hentosh, P. and Mo, H. (1999). Isoprenoid-mediated inhibition of mevalonate synthesis: Potential application to cancer . Proc. Soc. exp. Biol. Med 221 , pp. 294-311.
Peffley, D. M., Mo, H. and Elson, C. E. (1999). Targeting the action of isoprenoids and related phytochemicals to tumors. Nutritional Oncology , pp. 379-391.
Peffley, D. M., Gayen, A. K. and Morand, O. (1998). Down-regulation of 3-hydroxy-3-methylglutarly coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-{6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48-8071): comparison to simvastatin. Biochem Pharm 56 , pp. 439-449.
Peffley, D. M., Mehtani, S., Gong, Q., Panella, J., Subbiah, S. and Frankfater, A. (1998). In vivo expression of an alternatively spliced human tumor message that encodes a truncated form of cathepsin B. J. Biol. Chem. 273 , pp. 13236-13244.
Peffley, D. M. (1997). Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutarly coenzymeA reductase synthesis at a posttranscriptional level. Arch. Biochem. Biophys 337 , pp. 251-260.
Peffley, D. M. and Choi, J. (1995). 3'-untranslated sequences mediate posttranscriptional regulation of 3-hydroxy-3-methylglutarly coenzyme A reductase mRNA by 25-hydroxychelestrol. Biochem. J. 307 , pp. 233-238.
Peffley, D. M. and Gayen, A. K. (1995). Mevalonate regulates polysome distribution and blocks translationdependent suppression of 3-hydroxy-3-methylglutarly coenzyme A reductase mRNA: relationship to translational control. Somatic Cell molec. genet 21 , pp. 189-204.
Peffley, D. M. and Gayen, A. K. (1995). the length of 5' untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutarly coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate. Arch. Bioch. Biophys 322 , pp. 475-485.
Peffley, D. M., Pullen, G. L., Barsano, C. P. and Singh, K. R. (1994). The appearance, distribution, and longevity of receptor-[125I] T3 complexes within the nuclei of isolated rat hepatocytes. Thyroid 4 , pp. 305-312.
Peffley, D. M., Choi, J. and Lundquist, E. (1993). Inhibition of protein synthesis in baby hamster kidney cells blocks oxysterol-mediated suppression of 3-hydroxy-3-methylglutarly coenzyme A reductase mRNA at a post-transcriptional level. Biochem J 296 , pp. 859-866.
Peffley, D. M. (1992). Regulation of 3-hydroxy-3-methylglutarly coenxyme A reductase synthesis in Syrian Hamster C100 cells by mevinolin, 25-hydroxycholesterol and mevalonate:the role of posttranscritptional control. Somatic Cell Molec. Genet 18 , pp. 19-32.
Peffley, D. M., Miyake, J., Leonard, S., von Guten, C. and Sinensky, M. (1988). Further characterization of a somatic cell mutant defective in the regulation of 3-hydroxy-3-methylglutaryl coenzyme . A reductase. Somatic Cell Molec. Genet 14 , pp. 527-539.
Peffley, D. M., Von Guten, C., Leighton, J. and Sinensky, M. (1987). Progress in understanding mechanisms of the serum cholesterol risk factor in atherosclerosis. Somat Cell Molec. Genet. 13 , pp. 469-477.
Peffley, D. M., Dingermann, T., Bertling, W., Brechner, T., Nerke, K. and Sogin, M. (1986). Structure of two tRNA genes from Dictyostelium discoideum. Nucleic Acids Res. 14 , pp. 1127.
Peffley, D. M. and Sinensky, M. (1985). A reductase synthesis by a non-steryl mevalonate-derived product in Mev-1 cells: apparent translation control. J Biol. Chem 260 , pp. 9949-9952.
Peffley, D. M., Hahn, W. E., Chardhari, N., Beck, L. and Wilber, K. (1983). Genetic expression and postnatal development of the brain: some characteristics of nonpolyadenylated mRNAs. Cold Spring Harbor Symp. Quant. Biol 48 , pp. 465-475.
Peffley, D. M. and Sogin, M. L. (1982). Dictyostelium discoideum: its nucleotide sequence and association with repetive deoxyribonucleic acid. Biochem 20 , pp. 4015-4021.

Presentations

Peffley, D. M., Hentosh, P., Thomas, S., Bonchev, D., Hill, K., Hatcher, P., Thompson, S. K. and Kier, L. (April 9, 2008). Identifying potential Lung Cancer Protein Biomarkers By Bioinformatics and Mass Spectrometry ODU/Norfolk Sate/EVMS Research Expo .
Peffley, D. M., Hentosh, P., Thomas, S., Bonchev, D., Hill, K., Hatcher, P., Thompson, S. K. and Kier, L. (March , 2008). Identifying Potential Lung Cancer Biomarkers By Bioinformatics and Mass Spectrometry Molecular Medicine: Applying Current and Emerging Technologies Conference Orlando, FL.
Peffley, D. M., Thomas, S., Bonchev, D. and Hentosh, P. (June , 2007). Complex analysis of chromatin-associated genes in lung adenocarcinoma Summit on Systems Biology .
Peffley, D. M., Hentosh, P., Sheets, D., Sharma, C., Sipilina, N., Morgan, W. and Keightly, A. (April 5, 2007). Proteomic analysis of cellular responses to the anit-leukemic drug and nucleoside analog, 2-chloro-2'-deoxyadenosine (Cladribine) ODU/ Norfolk State/ EVMS Research Expo .
Peffley, D. M., Hentosh, P., Sharma, C., Morgan, W., Sipulina, N. and Keightly, A. (April 5, 2007). Regulation of 14-3-3 protein in human prostate tumor cells through the mTOR (mammalian target of rapamycin) signal transduction pathway ODU/Norfolk State/EVMS Research Expo .
Peffley, D. M., Buxton, B. A., Tanner, S. and Hentosh, P. (April , 2005). Regulation of inflammatory mediator secretion by dietary isoprenoids in an in vitro model of atherosclerosis Experimental Biology 2005 Meeting .
  • Cora Louise Carson Award, Tennessee Affiliate of the American Heart Association
  • New Investigator Award, American Heart Association, Tennessee Affiliate
  • 2008: Excellence Award in Molecular Medicine , Molecular Medicine
  • 2002: UHS Faculty Publication Award, UHS
  • 2002: University of Heakth Sciences research Support Award, University of Heakth Sciences
  • 1998: Travel Award, Basic Science Council of the American Heart Association
  • 1998: Travel Award, Basic Science Council of the American Heart Association
  • 1993: Travel Award, Basic Science Council of the American Heart Association