Christian Zemlin

757-683-3745
http://ww2.odu.edu/~czemlin/

418 4211 MONARCH WAY
NORFOLK, 23508

Ph.D. in Theoretical Physics, Humbolt University, (2002)

M.Sc. in Physics, Technical University Berlin, (1998)

B.S. in Mathematics, Technical University Berlin, (1994)

B.S. in Physics, Technical University Berlin, (1994)

Contracts, Grants and Sponsored Research

Osgood, C. J., Stacey, M. W., Elmustafa, A., Lai, N., Beebe, S. J., Hargrave, B., Zemlin, C. and Xu, X. "Addition of a micro-CT animal scanner to complement and expand current in vivo imaging capabilities" $423,850. Federal. -
"Scientist Development Grant" $308,000. May 2008 - December 2011
"Intramural Support Grant" $50,000. April 2008 - April 2009

Research Interests

Research Interests: Dr. Zemlin's research focuses on the mechanisms of arrhythmias. He uses voltage-sensitive fluorescent probes to experimentally study cardiac activity large-scale parallel computer modeling to understand how arrhythmias are initiated and maintained. Other research interest include imaging of tissue structure using optical clearing and confocal microscopy, and the general theory of excitable media.

Articles

Semenov, I., Grigoryev, S., Neuber, J. U., Zemlin, C., Pakhomova, O., Casciola, M. and Pakhomov, A. (2018). Excitation and injury of adult ventricular cardiomyocytes by nano- to millisecond electric shocks. Scientific Reports 8 , pp. 12.
Francis, M. P.., Breathwaite, E., Bulsheva, A. A.., V, F., Rodriguez, R. U.., Dutta, S., Semenov, I., Pakhomova, O., Huber, A., Tichy, A. M.., Chen, S. and Zemlin, C. (2017). Human placenta hydrogel reduces scarring in a rat model of cardiac ischemia and enhances cardiomyocyte and stem cell cultures. Acta Biomaterialia 52 , pp. 92-104.
Varghese, F., Neuber, J. U., Xie, F., Philpott, J. M., Pakhomov, A. and Zemlin, C. (2017). Low-energy defibrillation with nanosecond electric shocks. Cardiovascular Research 113 (14) , pp. 1789-1797.
Lin, X., Gemel, J., Glass, A., Zemlin, C., Taffet, S. M.., Beyer, E. C. . and Veenstra, R. (2010). Connexin40 and Connexin 43 Determine Gating Properties of Atrial Gap Junction Channels. J Mol Cell Cardiol (48) , pp. 238-245.
Wellner, M., Zemlin, C. and Persov, A. M. (2010). Frustrated drift of an anchored scroll wave filament and the geodesic principle. Phys Rev (82) , pp. 036122.
Caldwell, B., Mitrea, B., Pertsov, A. M.. and Zemlin, C. (2010). Probing Field-induced Tissue Polarization Using Transillumination Fluorescent Imaging. Biophysical Journal (99) , pp. 2058-66.
Zemlin, C., Mitrea, B. G.. and Pertsov, A. M.. (2009). Spontaneous Onset of Atrial Fibrillation. Physica D: Nonlinear Phenomena (238) , pp. 969-975.
Zemlin, C., Bernus, O., Matiukas, A. and Pertsov, A. M.. (2008). Extracting Intramural Wavefront Orientation From Optical Upstroke Shapes in Whole Hearts. Biophysical Journal (95) , pp. 942-50.
Smith, R., Matiukas , A. M.., Zemlin, C. and Pertsov, A. M.. (2008). Nondestructive Optical Determination of Fiber Organization in Whole Heart. Microscope Research and Technique (71) , pp. 510-16.
Hyatt, C. J.., Zemlin, C., Smith, R. M.., Matiukas, A. M.., Pertsov, A. M.. and Bernus, O. (2008). Reconstructing subsurface electrical wave orientation from cardiac epi-fluorescence recordings: Monte Carlo versus diffusion approximation. Optics Express (16) , pp. 13758-72.
Lin, X., Zemlin, C., Hennan, J., Petersen, J. and Veenstra, R. (2008). Rotigaptide Reduces the Inactivation of Ventricular Gap Junctions. Cardiovasc Res (79) , pp. 416-426.
Zemlin, C. and Pertsov, A. M.. (2007). Bradycardic onset of spiral wave re-entry: structural substrates.. Europace (9) , pp. 59-63.
Zemlin, C., Mukund, K., Biktashev, V. and Pertsov, A. M.. (2006). Dynamics of Bound States of Same-Chirality Spiral Waves. Phys Rev E (74) , pp. 016207.
Zemlin, C., Mironov, S. F.. and Pertsov, A. M.. (2006). Near-threshold Field Stimulation: Intramural Versus Surface Activation. Cardiovasc Res (69) , pp. 98-106.
Pertsov, A. M.., Zemlin, C., Hyatt, C. J.. and Bernus, O. (2006). What can we learn from the optically recorded epicardial action potential?. Biophys J (91) , pp. 3959-60.
Bernus, O., Zemlin, C., Zaritski, R., Mironov, S. F.. and Pertsov, A. M.. (2005). Alternating conduction in the ischemic border zone as a precursor of reentrant arrhythmias: a simulation study. Europace (7) , pp. 93-104.
Zemlin, C., Mukund, K., Wellner, M., Zaritski, R. and Pertsov, A. M.. (2005). Asymmetric Bound States of Spiral Pairs in Excitable Media . Phys Rev Lett (95) , pp. 098302.
Hyatt, C. J.., Mironov, S. F.., Vetter, F. J.., Zemlin, C. and Pertsov, A. M.. (2005). Optical action potential upstroke morphology reveals near-surface transmural propagation direction. Circ Res (97) , pp. 277-84.
Zemlin, C., Mironov, S. and Pertsov, A. M.. (2003). Delayed success in termination of three-dimensional reentry: role of surface polarization. J Cardiovasc Electrophysiol (14) , pp. S257-S263.
Zemlin, C., Storch, E. and Herzel, H. (2002). Alternans and 2:1 rhythms in an ionic model of heart cells. Biosystems (66) , pp. 1-10.
Bernus, O., Wilders, R., Zemlin, C., Verschelde, H. and Panfilov, A. V.. (2002). An efficient electrophysiological model of human ventricular cells. Am J Physiol (282) , pp. H2296-2308.
Panfilov, A. V.. and Zemlin, C. (2002). Wave propagation in an excitable medium with a negatively sloped restitution curve. Chaos (12) , pp. 800-807.
Zemlin, C. and Panfilov, A. V.. (2001). Spiral waves in excitable media with negative resitution . Phys Rev E (63:041912).

Book Chapters

Zemlin, C., Herzel, H., Ho, S. Y.. and Panfilov, A. V.. (2000). A realistic an deffecient model of excitation propagation in the human atria (pp. 29-34) Computer Stimunlation and Experimental Assessment of Cardiac Electrophysiology.

Conference Proceeding

Zemlin, C., Herzel, H. and Panfilov, A. V.. (2000). "Realistic modeling of cardiac arrhythmia" in Nonlinear Dynamics in the Life and Social Sciences (pp. 244-253) NATO ASI workshop.

Presentations

Zemlin, C. ( 2017). Heart attacks can give you theoretical biology: dynamics and geometry of cardiac arrhythmias Berlin, Germany .
Zemlin, C. (October 19, 2012). Cardiac Arrhythmias in Experiments and Computer Simulations Seminar at the ODU Biology Department .
Zemlin, C. (September 18, 2012). Cardiac Arrhythmias and the Geodesic Principle for Filaments in Excitable Media Seminar at the ODU Physics Department .
Zemlin, C. (September 13, 2012). Cardiac Arrhythmias, Optical Mapping, and the ECG Guest lecture in the course BME720 .
Zemlin, C. ( 2011). Anchoring of drifting spiral scroll waves to inexcitable inclusions World Congress on Mathematical Modeling and Computational Simulation of Cardiovascular and Cardiopulmonary Dynamics Williamsburg, Virginia.
Zemlin, C. (November 18, 2011). Automatically assessing mouse sociability in behavioral movies Joint ECE Departmental Seminar with Dr. Stephen Deutsch from EVMS .
Zemlin, C. (March 24, 2011). Understanding Cardiac Arrhythmias with Voltage-Sensitive Optical Imaging and Computer Simulations ECE Departmental Seminar .
Zemlin, C. ( 2010). Initiation mechanisms of reentrant arrhythmias Cardiovascular Research and Training Institute Salt Lake City, Utah.
Zemlin, C. ( 2009). Arrhythmia mechanisms in experiment and model Beijing, China.
Zemlin, C. ( 2007). Dynamics of bound states of spiral waves International workshop on non-linear dynamics in excitable media Ghent, Belgium.
Zemlin, C. ( 2006). Assessing the Net Polarization Caused by Shock-Induced Intramural Virtual Electrodes in Numerical Simulations and Transillumination Experiments Heart Rhythm Scientific Sessions Boston.
Zemlin, C. ( 2005). Shock-Induced Virtual Electrodes Inside the Myocardial Wall Heart Rhythm Scientific Sessions New Orleans.
Zemlin, C. ( 2005). Field Stimulation of Heart Tissue: Intramural Versus Surface Polarization SIAM Conference on Applications of Dynamical Systems Snowbird, UT.
Zemlin, C. ( 2004). Optical Mapping Experimental Biology Washington D.C..
Zemlin, C. ( 2004). Manifestations of Shock-Induced Surface Polarization and 3D Virtual Electrodes in Epifluorescence and Transillumination Heart Rhythm Scientific Sessions San Francisco.
Zemlin, C. ( 2003). The effect of spatially uniform electrical shocks on propagating and reentrant waves in cardiac tissue NASPE Scientific Sessions Washington D.C..
Zemlin, C. ( 2003). Understanding the Mechanisms of Defibrillation Syracuse, NY.
Zemlin, C. ( 2002). Delayed Success in the Termination of 3D Reentry: The Roles of Surface Polarization Computer Simulation and Experimental Assessment of Cardiac Electrophysiology Lausanne.
Zemlin, C. ( 2000). REalistic Modeling of Excitation Propagation in the Human Atria Computer Simulation and Experimental Assessment of Cardiac Electrophysiology Lausanne.
Zemlin, C. ( 2000). Realistic modeling of cardia arrythmias Nonlinear Dynamics in the Life and Social Sciences Moskau.
Zemlin, C. ( 2000). Modeling of Excitation Propagation in the Atria and the Quantification of Fibrillation Workshop on Mapping and Control of Complex Arrhythmias Montreal.
Zemlin, C. ( 1999). Realistic modeling of excitation propagation in the human atria Theory and Mathematics in Biology and Medicine Amsterdam.
Zemlin, C. ( 1999). Realistic Modeling of the Human Atria Vereiniging Nederlandse Theoretische Biologen Texel.
  • 2003: Postdoctoral Fellowship, American Heart Association
  • 1998: Heraeus Award,
  • 1991: Study Grant, German Study Foundation
  • 1991: First Prize in German National Mathematics Competition,