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Bioelectrics Calendar

CBE Seminar - Gale Craviso, PhD, U Nevada Reno

 - time/details may vary.
01/21/2014 9:00 AM - 01/21/2014 10:00 AM
IRP2 1st Floor Conference Room
"Neurosecretion evoked by nanosecond pulsed electric fields"

"Neurosecretion evoked by nanosecond pulsed electric fields"

Gale L. Craviso, Ph.D.


Department of Pharmacology

University of Nevada School of Medicine


Tuesday, January 21, 9-10AM

IRP2 First Floor Conference Room

4211 Monarch Way

Neuroendocrine adrenal chromaffin cells, a well-established model of neural-type cells, are exquisitely sensitive to 5 ns, high intensity (5-6 MV/m) electric pulses. When the cells are exposed to a single pulse, multiple types of voltage-gated Ca2+ channels are activated, resulting in Ca2+ influx, a rise in intracellular Ca2+ level, and the exocytotic release of catecholamine. While these findings point to the potential application of nanoelectropulses as a novel electric stimulation modality for modulating neural cell excitability and hence neurosecretion, the mechanism that is responsible for voltage-gated Ca2+ channel activation is not known. Experiments aimed at elucidating this mechanism are just now getting underway.