CBE Seminar - Gale Craviso, PhD, U Nevada Reno
- 01/21/2014 9:00 AM - 01/21/2014 10:00 AM
- IRP2 1st Floor Conference Room
- "Neurosecretion evoked by nanosecond pulsed electric fields"
"Neurosecretion evoked by nanosecond pulsed electric fields"
Gale L. Craviso, Ph.D.
Department of Pharmacology
University of Nevada School of Medicine
Tuesday, January 21, 9-10AM
IRP2 First Floor Conference Room
4211 Monarch Way
Neuroendocrine adrenal chromaffin cells, a well-established model of neural-type cells, are exquisitely sensitive to 5 ns, high intensity (5-6 MV/m) electric pulses. When the cells are exposed to a single pulse, multiple types of voltage-gated Ca2+ channels are activated, resulting in Ca2+ influx, a rise in intracellular Ca2+ level, and the exocytotic release of catecholamine. While these findings point to the potential application of nanoelectropulses as a novel electric stimulation modality for modulating neural cell excitability and hence neurosecretion, the mechanism that is responsible for voltage-gated Ca2+ channel activation is not known. Experiments aimed at elucidating this mechanism are just now getting underway.