CBE Seminar - David Mu, PhD, Eastern Virginia Medical School
- 10/08/2013 9:00 AM - 10/08/2013 10:00 AM
- IRP2 1st Floor Conference Room
- "Discovery of an amplified lung cancer gene and its connections to microRNAs"
"Discovery of an amplified lung cancer gene and its connections to microRNAs"
Seminar: Tuesday, October 8, 2013, 9-10AM
David Mu, PhD
Department of Microbiology and Molecular Cell Biology
Leroy T. Canoles Jr. Cancer Research Center
Eastern Virginia Medical School
We and others discovered that NKX2-1 is recurrently amplified in human lung cancer, implicating that NKX2-1 is an oncogene. Later studies suggest that NKX2-1 exhibits anti-oncogenic activities. By connecting NKX2-1 to the microRNA signaling network, we afford new insight on the dual functionalities of this critical lung cancer gene.