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Bioelectrics Calendar

CBE Seminar - David A. Dean, PhD, U. Rochester Medical School, Rochester, NY

R
 - time/details may vary.
 
Date/time
09/16/2011 10:00 AM - 09/16/2011 11:00 AM
Location
IRP2 1st Floor Conference Room
Description
"The cell biology of gene delivery: what happens to DNA after electroporation"

"The cell biology of gene delivery: what happens to DNA after electroporation"

David A. Dean, PhD

Professor, Department of Pediatrics

University of Rochester

Rochester, NY

http://www.urmc.rochester.edu/people/27094600-david-a-dean

Friday, September 16, 2011

10-11 AM

IRP#1 Conference Room, Second Floor

4111 Monarch Way (near Ted Constant Center)

Dr. Dean's Research:

Despite all of the hype regarding gene therapy, at present, gene therapy is a dream due to insufficient levels of gene transfer and expression at desired sites. One way to increase gene expression is to target more DNA to the cell nucleus. Since the nucleus is the site of transcription, without the movement of plasmids through the cytoplasm, translocation into the nucleus, and localization to the appropriate subnuclear domain, no gene expression, or "gene therapy" can take place. Ongoing projects in my laboratory are studying the mechanisms of cytoplasmic trafficking of plasmids along the cytoskeleton, plasmid nuclear entry, subnuclear organization, and exploiting what we learn to improve gene therapy. (www.urmc.rochester.edu)