Staff

  Philip J. Langlais, Ph.D.
  Vice Provost for Graduate Studies and Research
  (757) 683-6406
  planglai@odu.edu

  EDUCATION
  Salem State College - Salem, MA,Biology, B.A. 1969
  University of Texas Medical Branch -Galveston,TX, Physiology--M.A.,1974
  Northeastern University - Boston, MA Psychology, Ph.D. 1985

PROFESSIONAL POSITIONS
1981-1985

Assistant in Biochemistry, McLean Hospital, Belmont, MA
1981-1985

Associate in Neuropathology (Biochemistry), Harvard Medical School, Boston, MA
1984-1985

Health Care Scientist, VA Medical Center, Providence, RI
1985-1986

Research Fellow in Psychiatry, Harvard Medical School, Boston, MA
1985-1987

Health Science Specialist, VA Medical Center, Brockton, MA
1986-1987

Instructor in Psychiatry, Harvard Medical School, Boston, MA
1987-present

Health Care Scientist, VA Medical Center, San Diego, CA
1988-1992

Assistant Research Neuroscientist, Dept. of Neuroscience, UCSD School of Medicine, La Jolla, CA
1988-1990

Associate Professor, Department of Psychology, San Diego State University, San Diego, CA
1991-2003

Professor, Department of Psychology, San Diego State University, San Diego, CA
1993-1995

Associate Research Neuroscientist, Dept. of Neuroscience, UCSD School of Medicine, La Jolla, CA
1995-present

Research Neuroscientist, Dept. of Neuroscience, UCSD School of Medicine, La Jolla, CA
2001-2003

Associate Dean for Research & Graduate Studies, College of Sciences, San Diego State University, San Diego, CA
2003-present

Associate Vice President for Research and Dean of Graduate Studies, Old Dominion University, Norfolk, VA
2003-present

Professor, Department of Psychology, Old Dominion University, Norfolk, VA

HONORS & AWARDS
Golden Key Award 1969; VA Commendation 1978; VA Commendation 1980; AHA Outstanding Program Volunteer Award 1981; Phi Kappa Phi, 1986; Phi Beta Kappa, University Lecturer, 1994; Outstanding Faculty Award, SDSU, 2001; Psi Chi, SDSU Chapter Outstanding Professor Award, 2001.

RESEARCH PROJECTS DURING RECENT YEARS 
Histamine, IL-1 & Nitric Oxide in Wernicke Lesions",
P.I.: Philip J. Langlais, Ph.D.
Agency: National Institute of Neurological Disease and Stroke.
Type: RO1 (NS33157, Yrs 05-08) Period: 12/10/99-11/30/03
The long term objective of this project is to investigate the mechanisms of thiamine deficiency-induced lesions within the brain. The project studies the role of histamine and cytokines in the pathogenesis of increased vascular permeability, blood brain barrier breakdown and cell destruction with thalamus of the PTD model of Wernicke's encephalopathy. The project uses pharmacological and transgenic approaches to manipulating histamine, interleukin and TNF-? mediated signals and quantifying their effects on pathophysiological events.

"Neural and Cognitive Bases of Diencephalic Amnesia."
P.I.: Philip J. Langlais, Ph.D.
Agency: Department of Veterans Affairs
Type: V.A. Merit Award (#021347538-001, Yrs 12-15). Period: 10/01/98 - 09/31/01
The long term objective of this project is to determine the neural and cognitive bases of the learning and memory disturbances of diencephalic amnesia. The project has demonstrated a strong relation between damage to midline and intralaminar nuclei of the thalamus with severe learning and working memory deficits in the thiamine deficient rat model of WKS. The current project is examining the possibility that disturbances of attention, response selection/inhibition, and hypothesis testing underlie the learning impairments in this rat model. Furthermore, it is examining the hypothesis that damage to the intralaminar nuclei and the internal medullary lamina are responsible for these attention, impulsivity and response selection deficits.

"Chronic ETOH: Patho-Behavioral Lesions & Thiamine Status."
P.I.: Philip J. Langlais
Agency: National Institute of Alcoholism and Alcohol Abuse
Type: RO1 (AA10473): Period: 08/01/95 - 07/71/98
This project examined the etiological roles of chronic ethanol, thiamine deficiency and their interactions in the structural and behavioral disturbances observed in chronic alcoholism. The project treated adult rats with combined and single exposure to chronic ethanol consumption and repeated bouts of dietary thiamine deficiency. Thiamine and thiamine dependent enzymes were measured in specific brain regions and were correlated with measures of structural damage and cognitive and memory deficits.

SELECTED RECENT PUBLICATIONS
Chen L.H., Thielen V, Ciccia R.M., Langlais P.J. (2003) Effects of chronic ethanol feeding and thiamin    deficiency on antioxidant defenses in kidney and lung of rats. Alcohol Research 8:107-111.
Langlais PJ, McRee RC, Nalwalk JA, Hough LB (2002). Depletion of brain histamine protects against    thiamine deficiency-induced thalamic lesions in the rat. Metab Brain Disease 17:199-210.
Chen LH, Thielen V, Ciccia R, Langlais PJ (2002). Effects of chronic ethanol consumption and thiamin    deficiency on antioxidant defenses in heart and skeletal muscle of rats. Nutrition Research 22:835-845.
Langlais PJ (2001) Role of Histamine and Mast Cells in Metabolic Encephalopathy. In: Watanabe T,    Timmerman H, and Yanai K, eds. Histamine Research in the New Millenium, Elsevier Science,    Amsterdam, pp. 281-286.
Ciccia R, Langlais PJ (2000). An examination of the synergistic interaction of ethanol and thiamine    deficiency in the development of neurological signs and long-term cognitive and memory impairments.    Alcohol Clin Exp Res. 24:622-634.
McRee CR, Terry-Ferguson M, Langlais PJ, Chen Y, Nalwalk JW, Hough L. (2000). Increased histamine    release and granulocyte proliferation in a rat model of Wernicke's encephalopathy. Brain Res.    58:773-783.
Chen LH, Zhao Y, Ciccia R, Langlais PJ. (1999). Effects of long-term alcohol feeding and thiamin deficiency    on antioxidant defense systems in the liver and spleen of rats. Biochem. Arch. 15:103-116.
Langlais PJ. (1999) Thiamine Deficiency-Induced Damage in the Nervous System: A Review. In: Bondy SC,    ed. Chemicals and Neurodegenerative Disease. Prominent Press, Scottsdale AZ pp. 189-229.
Ferguson M, Dalve-Endres A, McRee RC, Langlais PJ (1999). Increased mast cell degranulation within    thalamus in early pre-lesion stages of an experimental model of Wernicke's encephalopathy. J.    Neuropath. Exp. Neurol. 58:773-783.
Savage LM, Castillo R, Langlais PJ. (1998). Effects of lesions of thalamic intralaminar nuclei and internal    medullary lamina on spatial memory and object discrimination. Behav. Neurosci. 112:1339-1352.
Langlais PJ, Hall T. (1998). Thiamine deficiency-induced disruptions in the diurnal rhythm and regulation    of body temperature in the rat. Metab Brain Dis 13:225-239.
Langlais PJ. (1998). Three Dimensional HPLC-EC Analyses of Regional Brain Neurotransmitter    Disturbances in Alzheimer's Disease With and Without Lewy Bodies. In: Qureshi AG, Parvez H, Caudy P,    & Parvez S, eds. Neurochemical Markers of Degenerative Nervous Diseases & Drug Addiction. Vol. 7. in    The Progress in HPLC-HPCE: VSP press, the Netherlands, pp.817-830.
Langlais PJ, Anderson G, Guo SX, Bondy SC (1997). Increased cerebral free radical production during    thiamine deficiency. Metab Brain Dis 12:137-143.
Langlais PJ, Zhang SX (1997). Cortical and subcortical white matter damage without Wernicke's    encephalopathy after recovery from thiamine deficiency in the rat. Alcohol Clin Exp Res 21:434-443.
Savage LM, Sweet AJ, Castillo R, Langlais PJ. (1997). The effects of lesions to thalamic lateral internal    medullary lamina and posterior nuclei on learning, memory, and habituation in the rat. Behav Brain Res    82:133-147.
Langlais PJ, Zhang SX (1997). Degeneration of cortical tracts in the absence of Wernicke lesions following    mild thiamine deficiency in the rat. Alcohol:Clin Exp Res 21:434-443.
Savage LM, Sweet AJ, Castillo R, Langlais PJ (1997). The effects of lesions to thalamic lateral internal    medullary lamina and posterior nuclei on learning, memory, and habituation in the rat. Behav. Brain.    Res. 83:133-147.
Langlais PJ, Zhang SX, Savage LM (1996). Neuropathology of thiamine deficiency: An update on the    comparative analysis of human disorders and experimental models. Metab. Brain. Dis 11:19-37.
Langlais, PJ (1995). Alcohol-related thiamine deficiency: Impact on cognitive and memory functioning.    Alcohol Health & Research World, 19:113-121.
Langlais PJ (1995). Pathogenesis and selectivity of diencephalic lesions in a rat model of thiamine    deficiency-induced Wernicke's Encephalopathy. Metab. Brain. Dis., 10:31-44.
Langlais PJ, Savage LM (1995). Thiamine deficiency in rats produces mild to severe cognitive and memory    deficits on spatial tasks which correlate with tissue loss in diencephalon, cortex and white matter.    Behav Brain Res., 68:75-89.
Savage LM, Langlais PJ (1995). Differential outcomes attenuate spatial memory impairments following    pyrithiamine-induced thiamine deficiency in rats. Psychobiology,. 23:153-160.
Zhang SX, Weilersbacher GS, Henderson SW, Corso T, Olney JW, Langlais PJ (1995). Excitotoxic    cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions. J.    Neuropathol Exp. Neurol., 54:255-267.
Jinnah, HA, Wojcik, BE, Hunt, M., Narang, N, Lee, KY, Goldstein, JK, Wamsley, JK, Langlais PJ, Friedman, T.    Dopamine deficiency in a genetic mouse model of Lesch-Nyhan Disease (1994). J. Neuroscience,    14:1164-1175.
Langlais PJ, Zhang SX, Weilersbacher G, Hough LB, Barke KE (1994). Histamine-mediated neuronal death    in a rat model of Wernicke's encephalopathy. J. Neurosci. Res., 38:565-574.
O'Connor D, Cervenka JH, Stone RA, Parmer RJ, Franco-Bourland RE, Madrazo I, Langlais PJ (1993).    Chromagranin A immunoreactivity in human cerebrospinal fluid: Properties, relationship to    noreadrenergic neuronal activity, and variation in neurologic disease. Neuroscience 56:999-1007.
Connor DJ, Langlais PJ, Langdon D, Thal LJ (1993). Effects of NBm lesion on T-maze performance and    thalamic biochemistry. Neurobiology of Aging, 14:535-537.
Langlais PJ, Connor DJ, Thal LJ (1993). Comparison of the effects of single and combined neurotoxic    lesions of the nucleus basalis magnocellularis and dorsal noradrenergic bundle on learning, reference,    and working memory in the rat. Behav. Brain. Res, 54:81-90.
Langlais PJ, Thal LJ, Hansen L, Galasko D, Alford M, Masliah E (1993). Neurotransmitters in basal ganglia    and cortex of Alzheimer's Disease with and without Lewy Bodies. Neurology, 43:1927-1934.
Langlais PJ, Zhang SH (1993). Extracellular glutamate is increased in thalamus during thiamine deficiency    induced lesions and is blocked by MK-801. J. Neurochem, 61:2175-2182.
Connor DJ, Dietz S, Langlais PJ, Thal, LJ (1992). Behavioral effects of concurrent lesions of the nucleus    basalis magnocellularis and the dorsal noradrenergic bundle. Experimental Neurology, 116:69-75.
Connor, DJ, Thal, LJ, Mandel, RJ, Langlais, PJ, Masliah, E (1992). Independent effects of age and NBM    lesion: Maze learning, cortical neurochemistry and morphometry. Behav Neurosci, 106:776-788.
Langlais PJ. Role of diencephalic lesions and thiamine deficiency in Korsakoff's amnesia: Insights from    animal models. In Larry R. Squire and Nelson Butters (Editors), Neuropsychology of Memory, pp.    440- 450. New York: The Guilford Press, 1992
Langlais PJ, Mandel RJ, Mair RG (1992). Diencephalic lesions, learning impairments and intact retrograde    memory following acute thiamine deficiency in the rat. Behav. Brain Res 48:177-185.
Langlais PJ, Wardlow ML, Yamamoto H (1992). Changes in CSF neurotransmitters in patients with    Infantile Spasms. Pediatric Neurology, 7:440-445.
Mair RG, Knoth RL, Rabchenuk SA, Langlais PJ (1991). Impairment of olfactory, auditory, and spatial serial    reversal learning in rats recovered from pyrithiamine induced thiamine deficiency. Behav Neuroscience,    105:360-374.
Mair RG, Otto TA, Knoth RL, Rabchenuk SA, Langlais PJ (1991). An analysis of aversively reinforced    learning in rats recovered from pyrithiamine induced thiamine deficiency. Behav Neuroscience,    105:351- 359.
Langlais PJ, Mair RG (1990). Protective effects of the glutamate antagonist MK-801 on pyrithiamine    induced lesions and amino acids changes in rat brain. J Neuroscience, 10:1664-1674.