The College of Arts and Letters comprises the departments of Art, Communication and Theatre Arts, English, Foreign Languages and Literatures, History, Music, Philosophy and Religious Studies, Political Science and Geography, Sociology and Criminal Justice, and Women's Studies. The college also administers the Interdisciplinary Studies Program, International Studies at the undergraduate level (BAIS) and graduate level (GPIS), the Institute of Humanities, the Institute for the Study of Race and Ethnicity, the Institute of Asian Studies, the Institute for Applied Ethics, the University Art Gallery, the Center for Regional and Global Study, the Social Science Research Center, the Filipino American Center, the Community Dance Program, Writing Tutorial Services, and the Old Dominion University Community Music Academy. The college also offers the F. Ludwig Diehn Concert Series, the Annual Literary Festival, and the Annual Film and Video Festival.

           In addition, the college offers M.A. degrees in Applied Linguistics, Applied Sociology, English, History, Humanities, and International Studies, the M.A./M.F.A. in Visual Studies, the M.F.A. in Creative Writing, and the Ph.D. in International Studies.

The College of Business and Public Administration comprises the departments of Accounting, Business Administration, Economics, Information Technology and Decision Sciences, and the Graduate Center for Urban Studies and Public Administration. It also provides an academic base for the U.S. Army Department of Military Science.

           Through the Graduate School of Business and Public Administration, the college administers the Ph.D. in Business Administration, the Urban Management concentration of the Urban Services Doctoral Program, and master's degrees in Business Administration, Accounting, Economics, Public Administration, and Urban Studies. In addition, the college offers a joint master's degree program in Computer Information Sciences with the Computer Science Department.

           The college also administers the following research and/or service units: Undergraduate and Graduate Advising, the Bureau of Research, Center for Asian Business, Economic Development Resource Center, Center for Economic Education, Entrepreneurial Center, Center for Global Business and Executive Education, Center for Insurance and Financial Services, International Maritime, Ports and Logistics Management Institute, Real Estate Center, Center for Regional Studies, and the Graduate Center for Urban Studies and Public Administration.

The Darden College of Education comprises the departments of Early Childhood, Speech Language Pathology and Special Education; Educational Curriculum and Instruction; Educational Leadership and Counseling; Exercise Science, Sport, Physical Education, and Recreation; and Occupational and Technical Studies. The college also administers the urban education concentration of the Urban Services Doctoral Program, Programs for Continued Learning, the Child Study Center, the Child Development Center, the Tidewater Virginia Writing Project, the Principals' Center of Hampton Roads, the Hampton Roads Institute for the Advanced Study of Teaching, the Military Career Transition Program, the Field-Based Graduate Programs for Teachers and School Administrators, the Wellness Institute and Research Center, the Pathways to Teaching Project, the Technical Assistance Center-5, the Commonwealth Special Education Endorsement Program, and TELETECHNET programs for Human Services, Occupational and Technical Studies, Special Education, and Teacher Education.

The College of Engineering and Technology comprises the departments of Aerospace Engineering, Civil and Environmental Engineering, Electrical and Computer Engineering, Engineering Management and Systems Engineering, Engineering Technology, Mechanical Engineering, and the Engineering Fundamentals Division. The college administers 10 enterprise centers: the Technology Applications Center; the Langley Full-Scale Wind Tunnel; the Applied Research Center; the Virginia Modeling, Analysis, and Simulation Center; the Center for Advanced Ship Repair and Maintenance; the Center for Continuing Engineering Education; the Virginia Space Flight Center; the Center for Advanced Engineering Environments; the Center for Bioelectrics; and the National Center for System of Systems. It administers the Commonwealth Graduate Engineering Program, the Virginia Consortium for Engineering and Science, the graduate programs in modeling and simulation, and the master's program in materials science and engineering. It also provides an organizational home for the Department of Naval Science.

The College of Health Sciences comprises the schools of Community and Environmental Health, Gene W. Hirschfeld Dental Hygiene, Medical Laboratory and Radiation Sciences, Nursing, and Physical Therapy. The college has programs in Community Health, Cytotechnology, Dental Hygiene, Environmental Health, Health Sciences, Medical Technology, Nuclear Medicine Technology, Occupational Safety, Nursing, and Physical Therapy. It also offers a joint Ophthalmic Technology Certificate and a Master's in Public Health with the Eastern Virginia Medical School, and it administers the Ph.D. in Urban Services/Health Services Concentration and the Continuing Healthcare Education Center (CHEC).

The College of Sciences includes the departments of Biological Sciences, Chemistry and Biochemistry, Computer Science, Mathematics and Statistics, Ocean, Earth and Atmospheric Sciences, Physics, and Psychology. The college also administers the following centers: Coastal Physical Oceanography, Computational Science and Quantitative Fisheries Ecology. It has a cooperative degree arrangement with Eastern Virginia Medical School (EVMS) in biomedical sciences (Ph.D.) and with the College of William and Mary, EVMS and Norfolk State University in clinical psychology (Psy.D.).